The association between triglyceride to high-density-lipoprotein cholesterol ratio and calcific aortic valve disease: a retrospective study
Abstract Background The ratio of triglycerides to high-density-lipoprotein cholesterol (TG/HDL-C) is increasingly recognized as a practical marker for insulin resistance and cardiovascular risk assessment. This retrospective study investigates the potential of the TG/HDL-C ratio to predict the devel...
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BMC
2024-12-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-024-04372-2 |
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| author | Zhihao Chen Luyao Liu Xueyan Jiao Yifan Zhang Fei Wang Yun Chen Zhenzhen Lan Xincan Liu |
| author_facet | Zhihao Chen Luyao Liu Xueyan Jiao Yifan Zhang Fei Wang Yun Chen Zhenzhen Lan Xincan Liu |
| author_sort | Zhihao Chen |
| collection | DOAJ |
| description | Abstract Background The ratio of triglycerides to high-density-lipoprotein cholesterol (TG/HDL-C) is increasingly recognized as a practical marker for insulin resistance and cardiovascular risk assessment. This retrospective study investigates the potential of the TG/HDL-C ratio to predict the development of calcific aortic valve disease (CAVD), thereby extending its applicability in cardiovascular diagnostics. Methods Data from 400 individuals, comprising 200 patients with diagnosed CAVD and 200 matched healthy controls, were analyzed. Clinical parameters were compared between groups, and logistic regression was utilized to explore the association of the TG/HDL-C ratio with CAVD. The diagnostic performance of the TG/HDL-C ratio was assessed using receiver operating characteristic (ROC) curves. Results The TG/HDL-C ratio was notably higher in the CAVD group than in the controls (Z = -7.98, P < 0.001). Multivariable logistic regression analysis indicated that the TG/HDL-C ratio is an independent predictor of CAVD after adjusting for confounders including gender. The ROC curve analysis revealed that the TG/HDL-C ratio achieved a sensitivity of 80.5%, a specificity of 59.5%, and an area under the curve (AUC) of 0.731 (P < 0.001), confirming its efficacy in predicting CAVD. Conclusions High TG/HDL-C ratio was significantly associated with the occurrence of CAVD, and the TG/HDL-C ratio could be used as a potential diagnostic tool and risk assessment indicator for CAVD. Clinical trial number Not applicable. |
| format | Article |
| id | doaj-art-9af0aefc2d8b4311bb88c184729d5d67 |
| institution | DOAJ |
| issn | 1471-2261 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
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| series | BMC Cardiovascular Disorders |
| spelling | doaj-art-9af0aefc2d8b4311bb88c184729d5d672025-08-20T02:40:14ZengBMCBMC Cardiovascular Disorders1471-22612024-12-012411810.1186/s12872-024-04372-2The association between triglyceride to high-density-lipoprotein cholesterol ratio and calcific aortic valve disease: a retrospective studyZhihao Chen0Luyao Liu1Xueyan Jiao2Yifan Zhang3Fei Wang4Yun Chen5Zhenzhen Lan6Xincan Liu7Heart Center, The First Affiliated Hospital of Henan University of Chinese MedicineThe First Clinical Medical College, Henan University of Chinese MedicineThe First Clinical Medical College, Henan University of Chinese MedicineThe First Clinical Medical College, Henan University of Chinese MedicinePhysical Examination Center, The First Affiliated Hospital of Henan University of Chinese MedicineHeart Center, The First Affiliated Hospital of Henan University of Chinese MedicineHeart Center, The First Affiliated Hospital of Henan University of Chinese MedicineHeart Center, The First Affiliated Hospital of Henan University of Chinese MedicineAbstract Background The ratio of triglycerides to high-density-lipoprotein cholesterol (TG/HDL-C) is increasingly recognized as a practical marker for insulin resistance and cardiovascular risk assessment. This retrospective study investigates the potential of the TG/HDL-C ratio to predict the development of calcific aortic valve disease (CAVD), thereby extending its applicability in cardiovascular diagnostics. Methods Data from 400 individuals, comprising 200 patients with diagnosed CAVD and 200 matched healthy controls, were analyzed. Clinical parameters were compared between groups, and logistic regression was utilized to explore the association of the TG/HDL-C ratio with CAVD. The diagnostic performance of the TG/HDL-C ratio was assessed using receiver operating characteristic (ROC) curves. Results The TG/HDL-C ratio was notably higher in the CAVD group than in the controls (Z = -7.98, P < 0.001). Multivariable logistic regression analysis indicated that the TG/HDL-C ratio is an independent predictor of CAVD after adjusting for confounders including gender. The ROC curve analysis revealed that the TG/HDL-C ratio achieved a sensitivity of 80.5%, a specificity of 59.5%, and an area under the curve (AUC) of 0.731 (P < 0.001), confirming its efficacy in predicting CAVD. Conclusions High TG/HDL-C ratio was significantly associated with the occurrence of CAVD, and the TG/HDL-C ratio could be used as a potential diagnostic tool and risk assessment indicator for CAVD. Clinical trial number Not applicable.https://doi.org/10.1186/s12872-024-04372-2TG/HDL-C ratioCalcific aortic valve diseaseEvaluation indicators |
| spellingShingle | Zhihao Chen Luyao Liu Xueyan Jiao Yifan Zhang Fei Wang Yun Chen Zhenzhen Lan Xincan Liu The association between triglyceride to high-density-lipoprotein cholesterol ratio and calcific aortic valve disease: a retrospective study BMC Cardiovascular Disorders TG/HDL-C ratio Calcific aortic valve disease Evaluation indicators |
| title | The association between triglyceride to high-density-lipoprotein cholesterol ratio and calcific aortic valve disease: a retrospective study |
| title_full | The association between triglyceride to high-density-lipoprotein cholesterol ratio and calcific aortic valve disease: a retrospective study |
| title_fullStr | The association between triglyceride to high-density-lipoprotein cholesterol ratio and calcific aortic valve disease: a retrospective study |
| title_full_unstemmed | The association between triglyceride to high-density-lipoprotein cholesterol ratio and calcific aortic valve disease: a retrospective study |
| title_short | The association between triglyceride to high-density-lipoprotein cholesterol ratio and calcific aortic valve disease: a retrospective study |
| title_sort | association between triglyceride to high density lipoprotein cholesterol ratio and calcific aortic valve disease a retrospective study |
| topic | TG/HDL-C ratio Calcific aortic valve disease Evaluation indicators |
| url | https://doi.org/10.1186/s12872-024-04372-2 |
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