Prognostic value of RS1333040 polymorphism in the ANRIL gene for coronary artery lesions and cardiovascular events in acute myocardial infarction patients
Background: The ANRIL gene is involved in atherosclerotic processes and acute myocardial infarction (AMI) initiation. The rs1333040 polymorphism shows potential association with coronary artery lesions and cardiovascular events in AMI patients, though data remains limited. Objectives: To determine t...
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Elsevier
2025-09-01
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| Series: | International Journal of Cardiology. Cardiovascular Risk and Prevention |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772487525000960 |
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| author | Nga Thi Ngoc Pham Lien Nguyen Thao Tran Cang Huynh Trung Hoang Minh Phan Dung The Bui Chau Minh Tran Thuc Tri Nguyen Phuong Minh Nguyen An Viet Tran |
| author_facet | Nga Thi Ngoc Pham Lien Nguyen Thao Tran Cang Huynh Trung Hoang Minh Phan Dung The Bui Chau Minh Tran Thuc Tri Nguyen Phuong Minh Nguyen An Viet Tran |
| author_sort | Nga Thi Ngoc Pham |
| collection | DOAJ |
| description | Background: The ANRIL gene is involved in atherosclerotic processes and acute myocardial infarction (AMI) initiation. The rs1333040 polymorphism shows potential association with coronary artery lesions and cardiovascular events in AMI patients, though data remains limited. Objectives: To determine the prognostic value of the rs1333040 ANRIL gene polymorphism for coronary artery lesions and cardiovascular events in AMI patients. Materials and methods: A cross-sectional descriptive study with longitudinal follow-up, conducted at the Interventional Cardiology Department of Can Tho Central General Hospital from October 2022 to June 2024. AMI patients underwent clinical examination, genetic sequencing, and cardiovascular event monitoring. Results: Among 150 patients (mean age 63.8 ± 10.3 years, 70.7 % male), genotype distribution showed TT as the most prevalent (55.3 %), TC (38.7 %), and CC (6.0 %). Diabetes mellitus was more prevalent in the TT genotype (28.9 %) versus TC (12.1 %) and CC (11.1 %). Severe coronary artery lesions were more common in TT genotype patients (65.7 % vs. 45.4 %; p < 0.05), with the T allele identified as a risk allele (OR = 2.22; 95 % CI: 1.29–3.81; p < 0.05). Multi-vessel coronary artery disease (CAD) was also more frequent in TT genotype patients (59.8 % vs. 49.2 %; p < 0.05). At the 9-month follow-up, event rates were: mortality 4.0 %, stroke 0.7 %, HF hospitalization 6.0 %, and MACE 10.7 %. Independent predictors for MACE initiation included age (HR = 1.05), diabetes (HR = 2.98), TT genotype (HR = 3.63), and T allele (HR = 3.39). Conclusion: AMI patients with the T allele of the rs1333040 ANRIL gene show more severe coronary lesions, higher multi-vessel disease risk, and poorer prognosis with increased MACE event probability. |
| format | Article |
| id | doaj-art-9aef08e9186f41d98db92f11945e551d |
| institution | Kabale University |
| issn | 2772-4875 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology. Cardiovascular Risk and Prevention |
| spelling | doaj-art-9aef08e9186f41d98db92f11945e551d2025-08-24T05:15:22ZengElsevierInternational Journal of Cardiology. Cardiovascular Risk and Prevention2772-48752025-09-012620045810.1016/j.ijcrp.2025.200458Prognostic value of RS1333040 polymorphism in the ANRIL gene for coronary artery lesions and cardiovascular events in acute myocardial infarction patientsNga Thi Ngoc Pham0Lien Nguyen Thao Tran1Cang Huynh Trung2Hoang Minh Phan3Dung The Bui4Chau Minh Tran5Thuc Tri Nguyen6Phuong Minh Nguyen7An Viet Tran8Faculty of Basic Science, Can Tho University of Medicine and Pharmacy, Can Tho City, 90000, Viet NamDepartment of Internal Medicine, Can Tho University of Medicine and Pharmacy, Can Tho City, 90000, Viet NamDepartment of Internal Medicine, Can Tho University of Medicine and Pharmacy, Can Tho City, 90000, Viet Nam; Department of Cardiology, Kien Giang Hospital, Kien Giang City, 91000, Viet NamHo Chi Minh City Hospital of Rehabilitation and Occupational Disease, 131 Au Duong Lan, Ward 2, District 8, Ho Chi Minh City, 71100, Viet NamDepartment of Internal Medicine, Can Tho University of Medicine and Pharmacy, Can Tho City, 90000, Viet Nam; Department of Cardiology, Ho Chi Minh University of Medicine and Pharmacy Center, 217 Hong Bang, Ward 11, District 5, Ho Chi Minh City, 71100, Viet NamDepartment of Internal Medicine, Can Tho University of Medicine and Pharmacy, Can Tho City, 90000, Viet NamCho Ray Hospital, 201B Nguyen Chi Thanh Street, Ward 12, District 5, Ho Chi Minh City, 71100, Viet NamFaculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho City, 90000, Viet NamDepartment of Internal Medicine, Can Tho University of Medicine and Pharmacy, Can Tho City, 90000, Viet Nam; Corresponding author.Background: The ANRIL gene is involved in atherosclerotic processes and acute myocardial infarction (AMI) initiation. The rs1333040 polymorphism shows potential association with coronary artery lesions and cardiovascular events in AMI patients, though data remains limited. Objectives: To determine the prognostic value of the rs1333040 ANRIL gene polymorphism for coronary artery lesions and cardiovascular events in AMI patients. Materials and methods: A cross-sectional descriptive study with longitudinal follow-up, conducted at the Interventional Cardiology Department of Can Tho Central General Hospital from October 2022 to June 2024. AMI patients underwent clinical examination, genetic sequencing, and cardiovascular event monitoring. Results: Among 150 patients (mean age 63.8 ± 10.3 years, 70.7 % male), genotype distribution showed TT as the most prevalent (55.3 %), TC (38.7 %), and CC (6.0 %). Diabetes mellitus was more prevalent in the TT genotype (28.9 %) versus TC (12.1 %) and CC (11.1 %). Severe coronary artery lesions were more common in TT genotype patients (65.7 % vs. 45.4 %; p < 0.05), with the T allele identified as a risk allele (OR = 2.22; 95 % CI: 1.29–3.81; p < 0.05). Multi-vessel coronary artery disease (CAD) was also more frequent in TT genotype patients (59.8 % vs. 49.2 %; p < 0.05). At the 9-month follow-up, event rates were: mortality 4.0 %, stroke 0.7 %, HF hospitalization 6.0 %, and MACE 10.7 %. Independent predictors for MACE initiation included age (HR = 1.05), diabetes (HR = 2.98), TT genotype (HR = 3.63), and T allele (HR = 3.39). Conclusion: AMI patients with the T allele of the rs1333040 ANRIL gene show more severe coronary lesions, higher multi-vessel disease risk, and poorer prognosis with increased MACE event probability.http://www.sciencedirect.com/science/article/pii/S2772487525000960Acute myocardial infarction (AMI)ANRIL geners1333040 polymorphism |
| spellingShingle | Nga Thi Ngoc Pham Lien Nguyen Thao Tran Cang Huynh Trung Hoang Minh Phan Dung The Bui Chau Minh Tran Thuc Tri Nguyen Phuong Minh Nguyen An Viet Tran Prognostic value of RS1333040 polymorphism in the ANRIL gene for coronary artery lesions and cardiovascular events in acute myocardial infarction patients International Journal of Cardiology. Cardiovascular Risk and Prevention Acute myocardial infarction (AMI) ANRIL gene rs1333040 polymorphism |
| title | Prognostic value of RS1333040 polymorphism in the ANRIL gene for coronary artery lesions and cardiovascular events in acute myocardial infarction patients |
| title_full | Prognostic value of RS1333040 polymorphism in the ANRIL gene for coronary artery lesions and cardiovascular events in acute myocardial infarction patients |
| title_fullStr | Prognostic value of RS1333040 polymorphism in the ANRIL gene for coronary artery lesions and cardiovascular events in acute myocardial infarction patients |
| title_full_unstemmed | Prognostic value of RS1333040 polymorphism in the ANRIL gene for coronary artery lesions and cardiovascular events in acute myocardial infarction patients |
| title_short | Prognostic value of RS1333040 polymorphism in the ANRIL gene for coronary artery lesions and cardiovascular events in acute myocardial infarction patients |
| title_sort | prognostic value of rs1333040 polymorphism in the anril gene for coronary artery lesions and cardiovascular events in acute myocardial infarction patients |
| topic | Acute myocardial infarction (AMI) ANRIL gene rs1333040 polymorphism |
| url | http://www.sciencedirect.com/science/article/pii/S2772487525000960 |
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