Nicotinamide mononucleotide biosynthesis and the F-actin cytoskeleton regulate spindle assembly and oocyte maturation quality in post-ovulatory aged porcine oocytes

Nicotinamide mononucleotide biosynthesis and the F-actin cytoskeleton regulate spindle assembly and oocyte maturation quality in post-ovulatory aged porcine oocytes

Abstract Background Post-ovulatory aging (POA) is associated with reduced fertilization rates and poor embryo quality both in vivo and in vitro. However, the relationship between nicotinamide adenine dinucleotide (NAD+) and the filamentous actin (F-actin) cytoskeleton in POA-induced oocytes remains...

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Bibliographic Details
Main Authors: Hyo-Jin Park, Seul-Gi Yang, Ji-Hyun Shin, Seung-Bin Yoon, Ji-Su Kim, Deog-Bon Koo
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Cell Communication and Signaling
Subjects:
F-actin cytoskeleton
Spindle assembly
NMN
NAD+ biosynthesis
Post-ovulatory aging
Porcine oocyte
Online Access:https://doi.org/10.1186/s12964-025-02200-4
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https://doi.org/10.1186/s12964-025-02200-4

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