LC-MS/MS Method for Determination of Hydroxychloroquine and Metabolites: Application in a Pharmacokinetic Study

LC-MS/MS Method for Determination of Hydroxychloroquine and Metabolites: Application in a Pharmacokinetic Study

Hydroxychloroquine (HCQ) was originally used as an antimalarial and immunomodulation drug. We developed and validated a simple and sensitive ultrahigh performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method for simultaneous quantitation of HCQ and its three metabolites in rat...

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Bibliographic Details
Main Authors:	Lili Cui, Zhipeng Wang, Shi Qiu, Mengwei Zhang, Yanping Liu, Fengjing Xu, Xinhua Song, Shouhong Gao, Wansheng Chen
Format:	Article
Language:	English
Published:	Wiley 2022-01-01
Series:	Journal of Analytical Methods in Chemistry
Online Access:	http://dx.doi.org/10.1155/2022/6058445
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