Immune correlates of protection as a game changer in tuberculosis vaccine development
Abstract The absence of validated correlates of protection (CoPs) hampers the rational design and clinical development of new tuberculosis vaccines. In this review, we provide an overview of the potential CoPs in tuberculosis vaccine research. Major hindrances and potential opportunities are then di...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-10-01
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| Series: | npj Vaccines |
| Online Access: | https://doi.org/10.1038/s41541-024-01004-w |
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| _version_ | 1850180488267825152 |
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| author | Jing Wang Xiao-Yong Fan Zhidong Hu |
| author_facet | Jing Wang Xiao-Yong Fan Zhidong Hu |
| author_sort | Jing Wang |
| collection | DOAJ |
| description | Abstract The absence of validated correlates of protection (CoPs) hampers the rational design and clinical development of new tuberculosis vaccines. In this review, we provide an overview of the potential CoPs in tuberculosis vaccine research. Major hindrances and potential opportunities are then discussed. Based on recent progress, it is reasonable to anticipate that success in the ongoing efforts to identify CoPs would be a game-changer in tuberculosis vaccine development. |
| format | Article |
| id | doaj-art-9ae5b685388f4ac0862c03a0e109e3c1 |
| institution | OA Journals |
| issn | 2059-0105 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Vaccines |
| spelling | doaj-art-9ae5b685388f4ac0862c03a0e109e3c12025-08-20T02:18:10ZengNature Portfolionpj Vaccines2059-01052024-10-019111310.1038/s41541-024-01004-wImmune correlates of protection as a game changer in tuberculosis vaccine developmentJing Wang0Xiao-Yong Fan1Zhidong Hu2Shanghai Public Health Clinical Center & Shanghai Institute of Infectious Diseases and Biosecurity, Fudan UniversityShanghai Public Health Clinical Center & Shanghai Institute of Infectious Diseases and Biosecurity, Fudan UniversityShanghai Public Health Clinical Center & Shanghai Institute of Infectious Diseases and Biosecurity, Fudan UniversityAbstract The absence of validated correlates of protection (CoPs) hampers the rational design and clinical development of new tuberculosis vaccines. In this review, we provide an overview of the potential CoPs in tuberculosis vaccine research. Major hindrances and potential opportunities are then discussed. Based on recent progress, it is reasonable to anticipate that success in the ongoing efforts to identify CoPs would be a game-changer in tuberculosis vaccine development.https://doi.org/10.1038/s41541-024-01004-w |
| spellingShingle | Jing Wang Xiao-Yong Fan Zhidong Hu Immune correlates of protection as a game changer in tuberculosis vaccine development npj Vaccines |
| title | Immune correlates of protection as a game changer in tuberculosis vaccine development |
| title_full | Immune correlates of protection as a game changer in tuberculosis vaccine development |
| title_fullStr | Immune correlates of protection as a game changer in tuberculosis vaccine development |
| title_full_unstemmed | Immune correlates of protection as a game changer in tuberculosis vaccine development |
| title_short | Immune correlates of protection as a game changer in tuberculosis vaccine development |
| title_sort | immune correlates of protection as a game changer in tuberculosis vaccine development |
| url | https://doi.org/10.1038/s41541-024-01004-w |
| work_keys_str_mv | AT jingwang immunecorrelatesofprotectionasagamechangerintuberculosisvaccinedevelopment AT xiaoyongfan immunecorrelatesofprotectionasagamechangerintuberculosisvaccinedevelopment AT zhidonghu immunecorrelatesofprotectionasagamechangerintuberculosisvaccinedevelopment |