Calcification markers and long-term outcomes of coronary artery bypass grafting
Aim. To assess the long-term outcomes of coronary artery bypass grafting (CABG) and their association with calcification biomarkers.Material and methods. The study included 129 men (mean age, 61,5±7,5 years) with coronary atherosclerosis who were admitted for CABG surgery. Patients were divided into...
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«FIRMA «SILICEA» LLC
2021-09-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/4450 |
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| author | E. M. Stakhneva E. V. Kashtanova A. V. Kurguzov N. A. Maslatsov Ya. V. Polonskaya I. S. Murashov A. M. Chernyavsky Yu. I. Ragino |
| author_facet | E. M. Stakhneva E. V. Kashtanova A. V. Kurguzov N. A. Maslatsov Ya. V. Polonskaya I. S. Murashov A. M. Chernyavsky Yu. I. Ragino |
| author_sort | E. M. Stakhneva |
| collection | DOAJ |
| description | Aim. To assess the long-term outcomes of coronary artery bypass grafting (CABG) and their association with calcification biomarkers.Material and methods. The study included 129 men (mean age, 61,5±7,5 years) with coronary atherosclerosis who were admitted for CABG surgery. Patients were divided into 2 groups: with favorable and unfavorable (death, myocardial infarction, stroke, surgery) 5-year prognosis after surgery. Before the surgery, the blood concentrations of calcification biomarkers (osteoprotegerin, osteopontin, osteonectin and osteocalcin) were determined in all patients.Results. Long-term outcomes of myocardial revascularization were studied in 92 patients (71%). An unfavorable long-term 5-year period was identified in 28 men (30,4%). In men with an unfavorable 5-year prognosis, the blood osteocalcin level before CABG was 1,2 times higher than in men with a favorable one. Multivariate linear regression showed that the risk of a 5-year unfavorable prognosis for coronary atherosclerosis after myocardial revascularization was associated with the blood osteocalcin concentration, determined before CABG (B=0,018, R2=0,285, p=0,008).Conclusion. The data obtained indicate the relevance of continuing studies on osteocalcin, including with respect to its contribution to coronary atherosclerosis and calcification. |
| format | Article |
| id | doaj-art-9ae31ea9ca8e405b8eb1f026a41c4708 |
| institution | Kabale University |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2021-09-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-9ae31ea9ca8e405b8eb1f026a41c47082025-08-20T03:57:22Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202021-09-0126810.15829/1560-4071-2021-44503298Calcification markers and long-term outcomes of coronary artery bypass graftingE. M. Stakhneva0E. V. Kashtanova1A. V. Kurguzov2N. A. Maslatsov3Ya. V. Polonskaya4I. S. Murashov5A. M. Chernyavsky6Yu. I. Ragino7Research Institute of Internal and Preventive Medicine — branch of the Federal Research Center Institute of Cytology and GeneticsResearch Institute of Internal and Preventive Medicine — branch of the Federal Research Center Institute of Cytology and GeneticsMeshalkin National Medical Research CenterResearch Institute of Internal and Preventive Medicine — branch of the Federal Research Center Institute of Cytology and GeneticsResearch Institute of Internal and Preventive Medicine — branch of the Federal Research Center Institute of Cytology and GeneticsMeshalkin National Medical Research CenterMeshalkin National Medical Research CenterResearch Institute of Internal and Preventive Medicine — branch of the Federal Research Center Institute of Cytology and GeneticsAim. To assess the long-term outcomes of coronary artery bypass grafting (CABG) and their association with calcification biomarkers.Material and methods. The study included 129 men (mean age, 61,5±7,5 years) with coronary atherosclerosis who were admitted for CABG surgery. Patients were divided into 2 groups: with favorable and unfavorable (death, myocardial infarction, stroke, surgery) 5-year prognosis after surgery. Before the surgery, the blood concentrations of calcification biomarkers (osteoprotegerin, osteopontin, osteonectin and osteocalcin) were determined in all patients.Results. Long-term outcomes of myocardial revascularization were studied in 92 patients (71%). An unfavorable long-term 5-year period was identified in 28 men (30,4%). In men with an unfavorable 5-year prognosis, the blood osteocalcin level before CABG was 1,2 times higher than in men with a favorable one. Multivariate linear regression showed that the risk of a 5-year unfavorable prognosis for coronary atherosclerosis after myocardial revascularization was associated with the blood osteocalcin concentration, determined before CABG (B=0,018, R2=0,285, p=0,008).Conclusion. The data obtained indicate the relevance of continuing studies on osteocalcin, including with respect to its contribution to coronary atherosclerosis and calcification.https://russjcardiol.elpub.ru/jour/article/view/4450coronary atherosclerosismyocardial infarctionlong-term outcomesosteocalcinosteoprotegerin |
| spellingShingle | E. M. Stakhneva E. V. Kashtanova A. V. Kurguzov N. A. Maslatsov Ya. V. Polonskaya I. S. Murashov A. M. Chernyavsky Yu. I. Ragino Calcification markers and long-term outcomes of coronary artery bypass grafting Российский кардиологический журнал coronary atherosclerosis myocardial infarction long-term outcomes osteocalcin osteoprotegerin |
| title | Calcification markers and long-term outcomes of coronary artery bypass grafting |
| title_full | Calcification markers and long-term outcomes of coronary artery bypass grafting |
| title_fullStr | Calcification markers and long-term outcomes of coronary artery bypass grafting |
| title_full_unstemmed | Calcification markers and long-term outcomes of coronary artery bypass grafting |
| title_short | Calcification markers and long-term outcomes of coronary artery bypass grafting |
| title_sort | calcification markers and long term outcomes of coronary artery bypass grafting |
| topic | coronary atherosclerosis myocardial infarction long-term outcomes osteocalcin osteoprotegerin |
| url | https://russjcardiol.elpub.ru/jour/article/view/4450 |
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