Prevalence of Amiodarone-Induced Thyrotoxicosis and Associated Risk Factors in Japanese Patients
Amiodarone is a widely used agent for life-threatening arrhythmias. Although amiodarone-induced thyrotoxicosis (AIT) is a major adverse effect that can cause recurrence of arrhythmias and exacerbation of heart failure, risk factors for AIT among amiodarone-treated Japanese patients have not been elu...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2014/534904 |
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| author | Toyoyoshi Uchida Takatoshi Kasai Atsutoshi Takagi Gaku Sekita Koji Komiya Kageumi Takeno Nayumi Shigihara Kazunori Shimada Katsumi Miyauchi Yoshio Fujitani Hiroyuki Daida Hirotaka Watada |
| author_facet | Toyoyoshi Uchida Takatoshi Kasai Atsutoshi Takagi Gaku Sekita Koji Komiya Kageumi Takeno Nayumi Shigihara Kazunori Shimada Katsumi Miyauchi Yoshio Fujitani Hiroyuki Daida Hirotaka Watada |
| author_sort | Toyoyoshi Uchida |
| collection | DOAJ |
| description | Amiodarone is a widely used agent for life-threatening arrhythmias. Although amiodarone-induced thyrotoxicosis (AIT) is a major adverse effect that can cause recurrence of arrhythmias and exacerbation of heart failure, risk factors for AIT among amiodarone-treated Japanese patients have not been elucidated. Here, we investigated the prevalence and predictive factors for AIT. The study subjects were 225 patients treated with amiodarone between 2008 and 2012, who were euthyroid before amiodarone therapy. All patients with AIT were diagnosed by measurement of thyroid hormones and ultrasonography. Among the 225 subjects, 13 patients (5.8%) developed AIT and all the patients were classified as Type 2 AIT. Baseline features of patients with AIT were not different from those who did not develop AIT, except for age (AIT, 55.1 ± 13.8, non-AIT, 68.1 ± 12.0 years, P<0.001). Multivariate analyses using the Cox proportional hazard model identified age as the sole determinant of AIT (hazard ratio: 0.927, 95% confidence interval: 0.891–0.964). Receiver operating characteristic curve analysis identified age of 63.5 years as the cutoff value for AIT with sensitivity of 70.3% and specificity of 69.2%. In summary, this study showed that the prevalence of AIT is 5.8% in Japanese patients treated with amiodarone and that young age is a risk factor for AIT. |
| format | Article |
| id | doaj-art-9ae05e982dbc4edbba2d34602057d4f1 |
| institution | OA Journals |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-9ae05e982dbc4edbba2d34602057d4f12025-08-20T02:20:26ZengWileyInternational Journal of Endocrinology1687-83371687-83452014-01-01201410.1155/2014/534904534904Prevalence of Amiodarone-Induced Thyrotoxicosis and Associated Risk Factors in Japanese PatientsToyoyoshi Uchida0Takatoshi Kasai1Atsutoshi Takagi2Gaku Sekita3Koji Komiya4Kageumi Takeno5Nayumi Shigihara6Kazunori Shimada7Katsumi Miyauchi8Yoshio Fujitani9Hiroyuki Daida10Hirotaka Watada11Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, JapanDepartment of Cardiology, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo 113-8421, JapanDepartment of Cardiology, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo 113-8421, JapanDepartment of Cardiology, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo 113-8421, JapanDepartment of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, JapanDepartment of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, JapanDepartment of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, JapanDepartment of Cardiology, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo 113-8421, JapanDepartment of Cardiology, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo 113-8421, JapanDepartment of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, JapanDepartment of Cardiology, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo 113-8421, JapanDepartment of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, JapanAmiodarone is a widely used agent for life-threatening arrhythmias. Although amiodarone-induced thyrotoxicosis (AIT) is a major adverse effect that can cause recurrence of arrhythmias and exacerbation of heart failure, risk factors for AIT among amiodarone-treated Japanese patients have not been elucidated. Here, we investigated the prevalence and predictive factors for AIT. The study subjects were 225 patients treated with amiodarone between 2008 and 2012, who were euthyroid before amiodarone therapy. All patients with AIT were diagnosed by measurement of thyroid hormones and ultrasonography. Among the 225 subjects, 13 patients (5.8%) developed AIT and all the patients were classified as Type 2 AIT. Baseline features of patients with AIT were not different from those who did not develop AIT, except for age (AIT, 55.1 ± 13.8, non-AIT, 68.1 ± 12.0 years, P<0.001). Multivariate analyses using the Cox proportional hazard model identified age as the sole determinant of AIT (hazard ratio: 0.927, 95% confidence interval: 0.891–0.964). Receiver operating characteristic curve analysis identified age of 63.5 years as the cutoff value for AIT with sensitivity of 70.3% and specificity of 69.2%. In summary, this study showed that the prevalence of AIT is 5.8% in Japanese patients treated with amiodarone and that young age is a risk factor for AIT.http://dx.doi.org/10.1155/2014/534904 |
| spellingShingle | Toyoyoshi Uchida Takatoshi Kasai Atsutoshi Takagi Gaku Sekita Koji Komiya Kageumi Takeno Nayumi Shigihara Kazunori Shimada Katsumi Miyauchi Yoshio Fujitani Hiroyuki Daida Hirotaka Watada Prevalence of Amiodarone-Induced Thyrotoxicosis and Associated Risk Factors in Japanese Patients International Journal of Endocrinology |
| title | Prevalence of Amiodarone-Induced Thyrotoxicosis and Associated Risk Factors in Japanese Patients |
| title_full | Prevalence of Amiodarone-Induced Thyrotoxicosis and Associated Risk Factors in Japanese Patients |
| title_fullStr | Prevalence of Amiodarone-Induced Thyrotoxicosis and Associated Risk Factors in Japanese Patients |
| title_full_unstemmed | Prevalence of Amiodarone-Induced Thyrotoxicosis and Associated Risk Factors in Japanese Patients |
| title_short | Prevalence of Amiodarone-Induced Thyrotoxicosis and Associated Risk Factors in Japanese Patients |
| title_sort | prevalence of amiodarone induced thyrotoxicosis and associated risk factors in japanese patients |
| url | http://dx.doi.org/10.1155/2014/534904 |
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