Beyond the infection: mapping the risk of cardiovascular events post-scrub typhus in a nationwide cohort study
Scrub typhus, caused by Orientia tsutsugamushi, often involves multiple organs, but its cardiovascular (CV) sequelae in survivors remain under-researched. This retrospective cohort study analyzed data from the National Health Insurance Research Database (NHIRD) spanning 2010–2015 to assess CV risks...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2025.2467766 |
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| author | Jih-Kai Yeh Victor Chien-Chia Wu Shao-Wei Chen Chia-Ling Wu Yu-Sheng Lin Chun-Wen Cheng Chih-Hsiang Chang Michael Wu Pao-Hsien Chu Shang-Hung Chang Yu-Tung Huang |
| author_facet | Jih-Kai Yeh Victor Chien-Chia Wu Shao-Wei Chen Chia-Ling Wu Yu-Sheng Lin Chun-Wen Cheng Chih-Hsiang Chang Michael Wu Pao-Hsien Chu Shang-Hung Chang Yu-Tung Huang |
| author_sort | Jih-Kai Yeh |
| collection | DOAJ |
| description | Scrub typhus, caused by Orientia tsutsugamushi, often involves multiple organs, but its cardiovascular (CV) sequelae in survivors remain under-researched. This retrospective cohort study analyzed data from the National Health Insurance Research Database (NHIRD) spanning 2010–2015 to assess CV risks among scrub typhus survivors. Excluding those with prior CV events, we focused on outcomes such as acute myocardial infarction (AMI), heart failure hospitalization (HFH), strokes, new-onset atrial fibrillation (AF), aortic aneurysm or dissection, venous thromboembolism (VTE), and CV death. From 2,269 scrub typhus patients without previous CV events (mean age 47.8 ± 16.1; 38.0% female), and a matched control group (n = 2,264), we observed a higher incidence of HFH, new-onset AF, and total CV events in the scrub typhus cohort. Adjusted hazard ratios (aHRs) were 1.97 (95% CI: 1.13–3.42) for HFH, 2.48 (95% CI: 1.23–5.0) for new-onset AF, and 1.43 (95% CI: 1.08–1.91) for total CV events. Other outcomes did not significantly differ. Scrub typhus survivors exhibit an increased risk of CV events, particularly HFH and new-onset AF, underscoring the importance of heightened physician awareness and post-infection cardiac surveillance. |
| format | Article |
| id | doaj-art-9ade1f7d06ee45059c4121f3418a91d3 |
| institution | Kabale University |
| issn | 2222-1751 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-9ade1f7d06ee45059c4121f3418a91d32025-08-20T03:47:58ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512025-12-0114110.1080/22221751.2025.2467766Beyond the infection: mapping the risk of cardiovascular events post-scrub typhus in a nationwide cohort studyJih-Kai Yeh0Victor Chien-Chia Wu1Shao-Wei Chen2Chia-Ling Wu3Yu-Sheng Lin4Chun-Wen Cheng5Chih-Hsiang Chang6Michael Wu7Pao-Hsien Chu8Shang-Hung Chang9Yu-Tung Huang10Division of Cardiology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan City, TaiwanDivision of Cardiology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan City, TaiwanDepartment of Cardiothoracic and Vascular Surgery, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan City, TaiwanCenter for Big Data Analytics and Statistics, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan City, TaiwanDepartment of Cardiology, Chang Gung Memorial Hospital, Chiayi, TaiwanDepartment of Infectious Diseases, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan City, TaiwanDepartment of Nephrology, Kidney Research Center, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan City, TaiwanDivison of Cardiovascular Medicine, Arrhythmia Services Section, Rhode Island Hospital, Warren Alpert School of Medicine, Brown University, Providence, USADivision of Cardiology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan City, TaiwanDivision of Cardiology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan City, TaiwanCenter for Big Data Analytics and Statistics, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan City, TaiwanScrub typhus, caused by Orientia tsutsugamushi, often involves multiple organs, but its cardiovascular (CV) sequelae in survivors remain under-researched. This retrospective cohort study analyzed data from the National Health Insurance Research Database (NHIRD) spanning 2010–2015 to assess CV risks among scrub typhus survivors. Excluding those with prior CV events, we focused on outcomes such as acute myocardial infarction (AMI), heart failure hospitalization (HFH), strokes, new-onset atrial fibrillation (AF), aortic aneurysm or dissection, venous thromboembolism (VTE), and CV death. From 2,269 scrub typhus patients without previous CV events (mean age 47.8 ± 16.1; 38.0% female), and a matched control group (n = 2,264), we observed a higher incidence of HFH, new-onset AF, and total CV events in the scrub typhus cohort. Adjusted hazard ratios (aHRs) were 1.97 (95% CI: 1.13–3.42) for HFH, 2.48 (95% CI: 1.23–5.0) for new-onset AF, and 1.43 (95% CI: 1.08–1.91) for total CV events. Other outcomes did not significantly differ. Scrub typhus survivors exhibit an increased risk of CV events, particularly HFH and new-onset AF, underscoring the importance of heightened physician awareness and post-infection cardiac surveillance.https://www.tandfonline.com/doi/10.1080/22221751.2025.2467766Scrub typhusOrientia tsutsugamushicardiovascular riskheart failure hospitalizationatrial fibrillation |
| spellingShingle | Jih-Kai Yeh Victor Chien-Chia Wu Shao-Wei Chen Chia-Ling Wu Yu-Sheng Lin Chun-Wen Cheng Chih-Hsiang Chang Michael Wu Pao-Hsien Chu Shang-Hung Chang Yu-Tung Huang Beyond the infection: mapping the risk of cardiovascular events post-scrub typhus in a nationwide cohort study Emerging Microbes and Infections Scrub typhus Orientia tsutsugamushi cardiovascular risk heart failure hospitalization atrial fibrillation |
| title | Beyond the infection: mapping the risk of cardiovascular events post-scrub typhus in a nationwide cohort study |
| title_full | Beyond the infection: mapping the risk of cardiovascular events post-scrub typhus in a nationwide cohort study |
| title_fullStr | Beyond the infection: mapping the risk of cardiovascular events post-scrub typhus in a nationwide cohort study |
| title_full_unstemmed | Beyond the infection: mapping the risk of cardiovascular events post-scrub typhus in a nationwide cohort study |
| title_short | Beyond the infection: mapping the risk of cardiovascular events post-scrub typhus in a nationwide cohort study |
| title_sort | beyond the infection mapping the risk of cardiovascular events post scrub typhus in a nationwide cohort study |
| topic | Scrub typhus Orientia tsutsugamushi cardiovascular risk heart failure hospitalization atrial fibrillation |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2025.2467766 |
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