Modifiable Risk Factors Including Self-Perceived Stress for Breast Cancer in Hong Kong: A Case-Control Study of 10 757 Subject
Background: In Hong Kong, breast cancer is the commonest female cancer. In addition to intrinsic risk factors that cannot be modified, other factors may be potentially modifiable. The objective of this report was to determine modifiable risk factors in association with breast cancer among Chinese wo...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-01-01
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| Series: | Clinical Medicine Insights: Oncology |
| Online Access: | https://doi.org/10.1177/11795549251314434 |
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| author | Winnie Yeo Lok-Wa Yuen Kelvin Kam-Fai Tsoi Emily Ying-Yang Chan Carol C Kwok Inda Soong Ting-Ying Ng Joanne Chiu Miranda Chan Sharon Wing-Wai Chan Ting-Ting Wong Yolanda Ho-Yan Chan Lawrence Pui-Ki Li Chun-Chung Yau Wai-Ka Hung Polly Suk-Yee Cheung |
| author_facet | Winnie Yeo Lok-Wa Yuen Kelvin Kam-Fai Tsoi Emily Ying-Yang Chan Carol C Kwok Inda Soong Ting-Ying Ng Joanne Chiu Miranda Chan Sharon Wing-Wai Chan Ting-Ting Wong Yolanda Ho-Yan Chan Lawrence Pui-Ki Li Chun-Chung Yau Wai-Ka Hung Polly Suk-Yee Cheung |
| author_sort | Winnie Yeo |
| collection | DOAJ |
| description | Background: In Hong Kong, breast cancer is the commonest female cancer. In addition to intrinsic risk factors that cannot be modified, other factors may be potentially modifiable. The objective of this report was to determine modifiable risk factors in association with breast cancer among Chinese women in our locality. Methods: This is a case-control study that enrolled breast cancer patients from the Hong Kong Breast Cancer Registry and healthy matched controls from the local community between 2014 and 2017. Potential risk factors were analyzed using multiple logistic regression. Results: In total, 5186 breast cancer patients and 5571 controls were recruited. Several modifiable risk factors were identified. Self-perceived high stress level (adjusted odd ratios [AOR]= 3.44; 95% confidence intervals [CI] = 3.13-3.78), dairy-rich diet (AOR = 3.33; 95% CI = 2.01-5.52), delayed child-bearing (AOR = 2.23; 95% CI = 1.79-2.79), meat-rich diet (AOR = 1.77; 95% CI = 1.54-2.04), ever use of oral contraceptives (AOR = 1.34; 95% CI = 1.22-1.47), nulliparity (AOR = 1.21; 95% CI = 1.08-1.35), and being overweight/obese (AOR = 1.21; 95% CI = 1.10-1.32) were found to be associated with an increased risk of breast cancer. On the other hand, breastfeeding (AOR = 0.76; 95% CI = 0.69-0.83) and exercise (odds ratio = 0.62; 95% CI = 0.56-0.68) were associated with decreased risk. Conclusions: In our locality, high-stress level, meat- and dairy-rich diet, reproductive history, use of oral contraceptives, and being overweight/obese were identified to be modifiable risk factors for breast cancer. Lifestyle modification may help reduce breast cancer incidence in the coming decades. |
| format | Article |
| id | doaj-art-9ad7ac88a0ec4e94ba9b5c4095517585 |
| institution | Kabale University |
| issn | 1179-5549 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical Medicine Insights: Oncology |
| spelling | doaj-art-9ad7ac88a0ec4e94ba9b5c40955175852025-01-25T07:03:31ZengSAGE PublishingClinical Medicine Insights: Oncology1179-55492025-01-011910.1177/11795549251314434Modifiable Risk Factors Including Self-Perceived Stress for Breast Cancer in Hong Kong: A Case-Control Study of 10 757 SubjectWinnie Yeo0Lok-Wa Yuen1Kelvin Kam-Fai Tsoi2Emily Ying-Yang Chan3Carol C Kwok4Inda Soong5Ting-Ying Ng6Joanne Chiu7Miranda Chan8Sharon Wing-Wai Chan9Ting-Ting Wong10Yolanda Ho-Yan Chan11Lawrence Pui-Ki Li12Chun-Chung Yau13Wai-Ka Hung14Polly Suk-Yee Cheung15Department of Clinical Oncology, Prince of Wales Hospital, Faculty of Medicine, The Chinese University of Hong Kong, Sha Tin, Hong KongDepartment of Surgery, Hong Kong Breast Cancer Foundation, North Point, Hong KongDepartment of Clinical Research and Biostatistics, Jockey Club School of Public Health and Primary Care, Prince of Wales Hospital, Sha Tin, Hong KongDepartment of Clinical Research and Biostatistics, Jockey Club School of Public Health and Primary Care, Prince of Wales Hospital, Sha Tin, Hong KongDepartment of Clinical Oncology, Princess Margaret Hospital, Kwai Chung, Hong KongDepartment of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong KongDepartment of Clinical Oncology, Tuen Mun Hospital, Tuen Mun, Hong KongDepartment of Medicine, Queen Mary Hospital, Pok Fu Lam, Hong KongDepartment of Surgery, Kwong Wah Hospital, Yau Ma Tei, Hong KongDepartment of Surgery, United Christian Hospital, Kwun Tong, Hong KongDepartment of Surgery, Hong Kong Breast Cancer Foundation, North Point, Hong KongDepartment of Surgery, Breast Health Clinic, CUHK Medical Centre, Sha Tin, Hong KongDepartment of Surgery, Hong Kong Breast Cancer Foundation, North Point, Hong KongDepartment of Surgery, Hong Kong Breast Cancer Foundation, North Point, Hong KongDepartment of Surgery, Hong Kong Breast Cancer Foundation, North Point, Hong KongDepartment of Surgery, Hong Kong Breast Cancer Foundation, North Point, Hong KongBackground: In Hong Kong, breast cancer is the commonest female cancer. In addition to intrinsic risk factors that cannot be modified, other factors may be potentially modifiable. The objective of this report was to determine modifiable risk factors in association with breast cancer among Chinese women in our locality. Methods: This is a case-control study that enrolled breast cancer patients from the Hong Kong Breast Cancer Registry and healthy matched controls from the local community between 2014 and 2017. Potential risk factors were analyzed using multiple logistic regression. Results: In total, 5186 breast cancer patients and 5571 controls were recruited. Several modifiable risk factors were identified. Self-perceived high stress level (adjusted odd ratios [AOR]= 3.44; 95% confidence intervals [CI] = 3.13-3.78), dairy-rich diet (AOR = 3.33; 95% CI = 2.01-5.52), delayed child-bearing (AOR = 2.23; 95% CI = 1.79-2.79), meat-rich diet (AOR = 1.77; 95% CI = 1.54-2.04), ever use of oral contraceptives (AOR = 1.34; 95% CI = 1.22-1.47), nulliparity (AOR = 1.21; 95% CI = 1.08-1.35), and being overweight/obese (AOR = 1.21; 95% CI = 1.10-1.32) were found to be associated with an increased risk of breast cancer. On the other hand, breastfeeding (AOR = 0.76; 95% CI = 0.69-0.83) and exercise (odds ratio = 0.62; 95% CI = 0.56-0.68) were associated with decreased risk. Conclusions: In our locality, high-stress level, meat- and dairy-rich diet, reproductive history, use of oral contraceptives, and being overweight/obese were identified to be modifiable risk factors for breast cancer. Lifestyle modification may help reduce breast cancer incidence in the coming decades.https://doi.org/10.1177/11795549251314434 |
| spellingShingle | Winnie Yeo Lok-Wa Yuen Kelvin Kam-Fai Tsoi Emily Ying-Yang Chan Carol C Kwok Inda Soong Ting-Ying Ng Joanne Chiu Miranda Chan Sharon Wing-Wai Chan Ting-Ting Wong Yolanda Ho-Yan Chan Lawrence Pui-Ki Li Chun-Chung Yau Wai-Ka Hung Polly Suk-Yee Cheung Modifiable Risk Factors Including Self-Perceived Stress for Breast Cancer in Hong Kong: A Case-Control Study of 10 757 Subject Clinical Medicine Insights: Oncology |
| title | Modifiable Risk Factors Including Self-Perceived Stress for Breast Cancer in Hong Kong: A Case-Control Study of 10 757 Subject |
| title_full | Modifiable Risk Factors Including Self-Perceived Stress for Breast Cancer in Hong Kong: A Case-Control Study of 10 757 Subject |
| title_fullStr | Modifiable Risk Factors Including Self-Perceived Stress for Breast Cancer in Hong Kong: A Case-Control Study of 10 757 Subject |
| title_full_unstemmed | Modifiable Risk Factors Including Self-Perceived Stress for Breast Cancer in Hong Kong: A Case-Control Study of 10 757 Subject |
| title_short | Modifiable Risk Factors Including Self-Perceived Stress for Breast Cancer in Hong Kong: A Case-Control Study of 10 757 Subject |
| title_sort | modifiable risk factors including self perceived stress for breast cancer in hong kong a case control study of 10 757 subject |
| url | https://doi.org/10.1177/11795549251314434 |
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