Outer retina micro-inflammation is driven by T cell responses prior to retinal degeneration in early age-related macular degeneration

Outer retina micro-inflammation is driven by T cell responses prior to retinal degeneration in early age-related macular degeneration

IntroductionAge-related macular degeneration (AMD) is a leading cause of blindness with limited treatment options. Dysfunction of the retinal pigment epithelium (RPE) is a unifying salient feature of the pathology and a primary end-point damage leading to complications such as geographic atrophy (GA...

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Main Authors: Lucas Stürzbecher, Hendrik Bartolomaeus, Theda U. P. Bartolomaeus, Sylvia Bolz, Andjela Sekulic, Marius Ueffing, Simon J. Clark, Nadine Reichhart, Sergio Crespo-Garcia, Nicola Wilck, Olaf Strauß
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
age related macular degeneration
geographic atrophy
T cells
adaptive immune system
neurodegeneration
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1520188/full
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