CDK9 recruits HUWE1 to degrade RARα and offers therapeutic opportunities for cutaneous T-cell lymphoma

CDK9 recruits HUWE1 to degrade RARα and offers therapeutic opportunities for cutaneous T-cell lymphoma

Abstract Cutaneous T-cell lymphoma (CTCL) is a heterogeneous non-Hodgkin lymphoma originating in the skin and invading the systemic hematopoietic system. Current treatments, including chemotherapy and monoclonal antibodies yielded limited responses with high incidence of side effects, highlighting t...

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Main Authors: Chen-Hui Luo, Li-Hong Hu, Jie-Yang Liu, Li Xia, Li Zhou, Ren-Hong Sun, Chen-Cen Lin, Xing Qiu, Biao Jiang, Meng-Ying Yang, Xue-Hong Zhang, Xiao-Bao Yang, Guo-Qiang Chen, Ying Lu
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54354-3
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