Prenatal to preschool exposure of nonylphenol and bisphenol A exposure and neurodevelopment in young children
Background: Nonylphenol (NP) and bisphenol A (BPA) are produced in large quantities worldwide as multipurpose agents. However, studies on relations between NP and BPA exposure and childhood neurodevelopment are few, and the results are inconsistent. This study aimed to investigate associations betwe...
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Elsevier
2024-01-01
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| Series: | Pediatrics and Neonatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957223001304 |
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| author | Pei-Wei Wang Yu-Fang Huang Chung-Hao Wang Li-Jung Fang Mei-Lien Chen |
| author_facet | Pei-Wei Wang Yu-Fang Huang Chung-Hao Wang Li-Jung Fang Mei-Lien Chen |
| author_sort | Pei-Wei Wang |
| collection | DOAJ |
| description | Background: Nonylphenol (NP) and bisphenol A (BPA) are produced in large quantities worldwide as multipurpose agents. However, studies on relations between NP and BPA exposure and childhood neurodevelopment are few, and the results are inconsistent. This study aimed to investigate associations between prenatal and early childhood NP and BPA exposure and neurodevelopment in mother–child pairs. Methods: Pregnant women at 27–38 weeks' gestation were recruited, as were children 2–3 years of age (n = 94) and 4–6 years of age (n = 56) years. Urine was collected to assess NP and BPA exposure. Bayley Scales of Infant and Toddler Development (3rd edition; Bayley-III), Wechsler Preschool and Primary Scale of Intelligence (4th edition), and the Full Scale Intelligence Quotient (WPPSI-IV-FSIQ) were used to assess the neurodevelopment of the children. Results: The detection rate and concentration of NP and BPA in the urine of children 4–6 years old were higher than in those 2–3 years old. Children were divided into a high concentration group (3rd tertile) and a reference group (1st and 2nd tertiles) based on natural log-transformed urine concentration of NP and BPA. Girls' Bayley-III motor scores in the high concentration group were higher than those of the BPA reference group of urine of mothers (β = 6.85, 95% confidence interval [CI]: 1.58–12.13). Boys' FSIQ in the higher concentration group were significantly lower than those in children 2–3 years old in the NP reference group (β = −11.29, 95% CI: −18.62 to −3.96) (all, p < 0.05). Conclusions: Prenatal and childhood exposure to NP and BPA may have different effects on the neurodevelopment of young children, and there are no consistent effects between boys and girls. |
| format | Article |
| id | doaj-art-9acbc61e958549ae90513f06ea628e51 |
| institution | OA Journals |
| issn | 1875-9572 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj-art-9acbc61e958549ae90513f06ea628e512025-08-20T02:00:34ZengElsevierPediatrics and Neonatology1875-95722024-01-01651768410.1016/j.pedneo.2023.04.011Prenatal to preschool exposure of nonylphenol and bisphenol A exposure and neurodevelopment in young childrenPei-Wei Wang0Yu-Fang Huang1Chung-Hao Wang2Li-Jung Fang3Mei-Lien Chen4Institute of Environmental and Occupational Health Sciences, School of Medicine, Yangming Campus, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Pediatrics, Heping Fuyou Branch, Taipei City Hospital, Taipei, TaiwanInstitute of Environmental and Occupational Health Sciences, School of Medicine, Yangming Campus, National Yang Ming Chiao Tung University, Taipei, Taiwan; Corresponding author. Institute of Environmental and Occupational Health Sciences, School of Medicine, Yangming Campus, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St., Beitou Dist., Taipei City 112304, Taiwan.Department of Pediatrics, Heping Fuyou Branch, Taipei City Hospital, Taipei, TaiwanDepartment of Pediatrics, Heping Fuyou Branch, Taipei City Hospital, Taipei, TaiwanInstitute of Environmental and Occupational Health Sciences, School of Medicine, Yangming Campus, National Yang Ming Chiao Tung University, Taipei, Taiwan; Corresponding author. Institute of Environmental and Occupational Health Sciences, School of Medicine, Yangming Campus, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St., Beitou Dist., Taipei City 112304, Taiwan.Background: Nonylphenol (NP) and bisphenol A (BPA) are produced in large quantities worldwide as multipurpose agents. However, studies on relations between NP and BPA exposure and childhood neurodevelopment are few, and the results are inconsistent. This study aimed to investigate associations between prenatal and early childhood NP and BPA exposure and neurodevelopment in mother–child pairs. Methods: Pregnant women at 27–38 weeks' gestation were recruited, as were children 2–3 years of age (n = 94) and 4–6 years of age (n = 56) years. Urine was collected to assess NP and BPA exposure. Bayley Scales of Infant and Toddler Development (3rd edition; Bayley-III), Wechsler Preschool and Primary Scale of Intelligence (4th edition), and the Full Scale Intelligence Quotient (WPPSI-IV-FSIQ) were used to assess the neurodevelopment of the children. Results: The detection rate and concentration of NP and BPA in the urine of children 4–6 years old were higher than in those 2–3 years old. Children were divided into a high concentration group (3rd tertile) and a reference group (1st and 2nd tertiles) based on natural log-transformed urine concentration of NP and BPA. Girls' Bayley-III motor scores in the high concentration group were higher than those of the BPA reference group of urine of mothers (β = 6.85, 95% confidence interval [CI]: 1.58–12.13). Boys' FSIQ in the higher concentration group were significantly lower than those in children 2–3 years old in the NP reference group (β = −11.29, 95% CI: −18.62 to −3.96) (all, p < 0.05). Conclusions: Prenatal and childhood exposure to NP and BPA may have different effects on the neurodevelopment of young children, and there are no consistent effects between boys and girls.http://www.sciencedirect.com/science/article/pii/S1875957223001304bisphenol Achildrenneurodevelopmentnonylphenol |
| spellingShingle | Pei-Wei Wang Yu-Fang Huang Chung-Hao Wang Li-Jung Fang Mei-Lien Chen Prenatal to preschool exposure of nonylphenol and bisphenol A exposure and neurodevelopment in young children Pediatrics and Neonatology bisphenol A children neurodevelopment nonylphenol |
| title | Prenatal to preschool exposure of nonylphenol and bisphenol A exposure and neurodevelopment in young children |
| title_full | Prenatal to preschool exposure of nonylphenol and bisphenol A exposure and neurodevelopment in young children |
| title_fullStr | Prenatal to preschool exposure of nonylphenol and bisphenol A exposure and neurodevelopment in young children |
| title_full_unstemmed | Prenatal to preschool exposure of nonylphenol and bisphenol A exposure and neurodevelopment in young children |
| title_short | Prenatal to preschool exposure of nonylphenol and bisphenol A exposure and neurodevelopment in young children |
| title_sort | prenatal to preschool exposure of nonylphenol and bisphenol a exposure and neurodevelopment in young children |
| topic | bisphenol A children neurodevelopment nonylphenol |
| url | http://www.sciencedirect.com/science/article/pii/S1875957223001304 |
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