ANGPTL4-mediated microglial lipid droplet accumulation: Bridging Alzheimer's disease and obesity

ANGPTL4-mediated microglial lipid droplet accumulation: Bridging Alzheimer's disease and obesity

Increasing evidence suggests that metabolic disorders such as obesity are implicated in the development of Alzheimer's disease (AD). The pathological buildup of lipids in microglia is regarded as a key indicator in brain aging and the progression of AD, yet the mechanisms behind this process re...

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Bibliographic Details
Main Authors: Nan Li, Xiaojun Wang, Ruilang Lin, Fuxia Yang, Hung-Chen Chang, Xuchao Gu, Jun Shu, Guidong Liu, Yongfu Yu, Wenshi Wei, Zhijun Bao
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Obesity
Aging
Microglia
ANGPTL4
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996124003437
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