MRI Guided Focused Ultrasound Thalamotomy for Moderate-to-Severe Tremor in Parkinson’s Disease
Background. Thalamotomy is effective in alleviating tremor in Parkinson’s disease (PD). Methods. Seven PD patients, mean age 59.4 ± 9.8 years (range, 46–74) with a mean disease duration of 5.4 ± 2.8 years (range, 2–10) suffering from severe refractory tremor, underwent ventral intermediate nucleus t...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2015/219149 |
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| author | Ilana Schlesinger Ayelet Eran Alon Sinai Ilana Erikh Maria Nassar Dorith Goldsher Menashe Zaaroor |
| author_facet | Ilana Schlesinger Ayelet Eran Alon Sinai Ilana Erikh Maria Nassar Dorith Goldsher Menashe Zaaroor |
| author_sort | Ilana Schlesinger |
| collection | DOAJ |
| description | Background. Thalamotomy is effective in alleviating tremor in Parkinson’s disease (PD). Methods. Seven PD patients, mean age 59.4 ± 9.8 years (range, 46–74) with a mean disease duration of 5.4 ± 2.8 years (range, 2–10) suffering from severe refractory tremor, underwent ventral intermediate nucleus thalamotomy using MRI guided focused ultrasound (MRgFUS), an innovative technology that enables noninvasive surgery. Results. Tremor stopped in the contralateral upper extremity in all patients immediately following treatment. Total UPDRS decreased from 37.4 ± 12.2 to 18.8 ± 11.1 (p=0.007) and PDQ-39 decreased from 42.3 ± 16.4 to 21.6 ± 10.8 (p=0.008) following MRgFUS. These effects were sustained (mean follow-up 7.3 months). Adverse events during MRgFUS included headache (n=3), dizziness (n=2), vertigo (n=4), and lip paresthesia (n=1) and following MRgFUS were hypogeusia (n=1), unsteady feeling when walking (n=1, resolved), and disturbance when walking tandem (n=1, resolved). Conclusions. Thalamotomy using MRgFUS is safe and effective in PD patients. Large randomized studies are needed to assess prolonged efficacy and safety. |
| format | Article |
| id | doaj-art-9ac595ab7559422bb0fe098fffd4900d |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-9ac595ab7559422bb0fe098fffd4900d2025-02-03T05:59:34ZengWileyParkinson's Disease2090-80832042-00802015-01-01201510.1155/2015/219149219149MRI Guided Focused Ultrasound Thalamotomy for Moderate-to-Severe Tremor in Parkinson’s DiseaseIlana Schlesinger0Ayelet Eran1Alon Sinai2Ilana Erikh3Maria Nassar4Dorith Goldsher5Menashe Zaaroor6Department of Neurology, Rambam Health Care Campus, Haifa, IsraelDepartment of Radiology, Rambam Health Care Campus, Haifa, IsraelDepartment of Neurology, Rambam Health Care Campus, Haifa, IsraelDepartment of Neurology, Rambam Health Care Campus, Haifa, IsraelDepartment of Neurology, Rambam Health Care Campus, Haifa, IsraelTechnion Faculty of Medicine, Haifa, IsraelTechnion Faculty of Medicine, Haifa, IsraelBackground. Thalamotomy is effective in alleviating tremor in Parkinson’s disease (PD). Methods. Seven PD patients, mean age 59.4 ± 9.8 years (range, 46–74) with a mean disease duration of 5.4 ± 2.8 years (range, 2–10) suffering from severe refractory tremor, underwent ventral intermediate nucleus thalamotomy using MRI guided focused ultrasound (MRgFUS), an innovative technology that enables noninvasive surgery. Results. Tremor stopped in the contralateral upper extremity in all patients immediately following treatment. Total UPDRS decreased from 37.4 ± 12.2 to 18.8 ± 11.1 (p=0.007) and PDQ-39 decreased from 42.3 ± 16.4 to 21.6 ± 10.8 (p=0.008) following MRgFUS. These effects were sustained (mean follow-up 7.3 months). Adverse events during MRgFUS included headache (n=3), dizziness (n=2), vertigo (n=4), and lip paresthesia (n=1) and following MRgFUS were hypogeusia (n=1), unsteady feeling when walking (n=1, resolved), and disturbance when walking tandem (n=1, resolved). Conclusions. Thalamotomy using MRgFUS is safe and effective in PD patients. Large randomized studies are needed to assess prolonged efficacy and safety.http://dx.doi.org/10.1155/2015/219149 |
| spellingShingle | Ilana Schlesinger Ayelet Eran Alon Sinai Ilana Erikh Maria Nassar Dorith Goldsher Menashe Zaaroor MRI Guided Focused Ultrasound Thalamotomy for Moderate-to-Severe Tremor in Parkinson’s Disease Parkinson's Disease |
| title | MRI Guided Focused Ultrasound Thalamotomy for Moderate-to-Severe Tremor in Parkinson’s Disease |
| title_full | MRI Guided Focused Ultrasound Thalamotomy for Moderate-to-Severe Tremor in Parkinson’s Disease |
| title_fullStr | MRI Guided Focused Ultrasound Thalamotomy for Moderate-to-Severe Tremor in Parkinson’s Disease |
| title_full_unstemmed | MRI Guided Focused Ultrasound Thalamotomy for Moderate-to-Severe Tremor in Parkinson’s Disease |
| title_short | MRI Guided Focused Ultrasound Thalamotomy for Moderate-to-Severe Tremor in Parkinson’s Disease |
| title_sort | mri guided focused ultrasound thalamotomy for moderate to severe tremor in parkinson s disease |
| url | http://dx.doi.org/10.1155/2015/219149 |
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