Circular RNA circDCUN1D4 suppresses hepatocellular carcinoma development via targeting the miR-590-5p/ TIMP3 axis
Abstract Hepatocellular carcinoma (HCC) is a major global health concern, necessitating innovative therapeutic strategies. In this study, we investigated the functional role of circular RNA circDCUN1D4 in HCC progression and its potential therapeutic implications. It was found that HCC patients exhi...
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| Format: | Article |
| Language: | English |
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BMC
2025-03-01
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| Series: | Molecular Cancer |
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| Online Access: | https://doi.org/10.1186/s12943-025-02300-2 |
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| author | Hongyu Li Bing Su Yan Jiang Boyang Zhang Rulong Du Can Song Bin Hou Kun Xu Lida Wu Yuchun Gu |
| author_facet | Hongyu Li Bing Su Yan Jiang Boyang Zhang Rulong Du Can Song Bin Hou Kun Xu Lida Wu Yuchun Gu |
| author_sort | Hongyu Li |
| collection | DOAJ |
| description | Abstract Hepatocellular carcinoma (HCC) is a major global health concern, necessitating innovative therapeutic strategies. In this study, we investigated the functional role of circular RNA circDCUN1D4 in HCC progression and its potential therapeutic implications. It was found that HCC patients exhibiting higher levels of circDCUN1D4 demonstrated a more favorable survival rate. Furthermore, we revealed that circDCUN1D4 suppressed HCC cell proliferation, migration, and invasion. Mechanistically, circDCUN1D4 was identified as a sponge for miR-590-5p, leading to the downregulation of its downstream target, Tissue Inhibitor of Metalloproteinase 3 (TIMP3). Importantly, circDCUN1D4 administration through In vivo jet-PEI exhibited a robust inhibitory effect on tumor progression without causing notable toxicity in mice. Overall, our findings highlight circDCUN1D4 as a promising therapeutic candidate for HCC, unraveling its intricate regulatory role through the miR-590-5p/TIMP3 axis. This study contributes valuable insights into the potential clinical applications of circRNA-based therapies for HCC. |
| format | Article |
| id | doaj-art-9ac26a4fd017427d88b447ae907e9fb9 |
| institution | DOAJ |
| issn | 1476-4598 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj-art-9ac26a4fd017427d88b447ae907e9fb92025-08-20T02:49:26ZengBMCMolecular Cancer1476-45982025-03-0124111710.1186/s12943-025-02300-2Circular RNA circDCUN1D4 suppresses hepatocellular carcinoma development via targeting the miR-590-5p/ TIMP3 axisHongyu Li0Bing Su1Yan Jiang2Boyang Zhang3Rulong Du4Can Song5Bin Hou6Kun Xu7Lida Wu8Yuchun Gu9College of Chemistry and Lie Science, Beijing University of TechnologyCollege of Chemistry and Lie Science, Beijing University of TechnologyDepartment of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University)Allife Medical Science and Technology Co., Ltd. Economic and Technological Development ZoneAllife Medical Science and Technology Co., Ltd. Economic and Technological Development ZoneAllife Medical Science and Technology Co., Ltd. Economic and Technological Development ZoneAllife Medical Science and Technology Co., Ltd. Economic and Technological Development ZoneCollege of Chemistry and Lie Science, Beijing University of TechnologyAllife Medical Science and Technology Co., Ltd. Economic and Technological Development ZoneAllife Medical Science and Technology Co., Ltd. Economic and Technological Development ZoneAbstract Hepatocellular carcinoma (HCC) is a major global health concern, necessitating innovative therapeutic strategies. In this study, we investigated the functional role of circular RNA circDCUN1D4 in HCC progression and its potential therapeutic implications. It was found that HCC patients exhibiting higher levels of circDCUN1D4 demonstrated a more favorable survival rate. Furthermore, we revealed that circDCUN1D4 suppressed HCC cell proliferation, migration, and invasion. Mechanistically, circDCUN1D4 was identified as a sponge for miR-590-5p, leading to the downregulation of its downstream target, Tissue Inhibitor of Metalloproteinase 3 (TIMP3). Importantly, circDCUN1D4 administration through In vivo jet-PEI exhibited a robust inhibitory effect on tumor progression without causing notable toxicity in mice. Overall, our findings highlight circDCUN1D4 as a promising therapeutic candidate for HCC, unraveling its intricate regulatory role through the miR-590-5p/TIMP3 axis. This study contributes valuable insights into the potential clinical applications of circRNA-based therapies for HCC.https://doi.org/10.1186/s12943-025-02300-2circDCUN1D4Hepatocellular carcinomamiR-590-5pTIMP3 |
| spellingShingle | Hongyu Li Bing Su Yan Jiang Boyang Zhang Rulong Du Can Song Bin Hou Kun Xu Lida Wu Yuchun Gu Circular RNA circDCUN1D4 suppresses hepatocellular carcinoma development via targeting the miR-590-5p/ TIMP3 axis Molecular Cancer circDCUN1D4 Hepatocellular carcinoma miR-590-5p TIMP3 |
| title | Circular RNA circDCUN1D4 suppresses hepatocellular carcinoma development via targeting the miR-590-5p/ TIMP3 axis |
| title_full | Circular RNA circDCUN1D4 suppresses hepatocellular carcinoma development via targeting the miR-590-5p/ TIMP3 axis |
| title_fullStr | Circular RNA circDCUN1D4 suppresses hepatocellular carcinoma development via targeting the miR-590-5p/ TIMP3 axis |
| title_full_unstemmed | Circular RNA circDCUN1D4 suppresses hepatocellular carcinoma development via targeting the miR-590-5p/ TIMP3 axis |
| title_short | Circular RNA circDCUN1D4 suppresses hepatocellular carcinoma development via targeting the miR-590-5p/ TIMP3 axis |
| title_sort | circular rna circdcun1d4 suppresses hepatocellular carcinoma development via targeting the mir 590 5p timp3 axis |
| topic | circDCUN1D4 Hepatocellular carcinoma miR-590-5p TIMP3 |
| url | https://doi.org/10.1186/s12943-025-02300-2 |
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