Inhibition of transcription by dactinomycin reveals a new characteristic of immunogenic cell stress

Inhibition of transcription by dactinomycin reveals a new characteristic of immunogenic cell stress

Abstract Chemotherapy still constitutes the standard of care for the treatment of most neoplastic diseases. Certain chemotherapeutics from the oncological armamentarium are able to trigger pre‐mortem stress signals that lead to immunogenic cell death (ICD), thus inducing an antitumor immune response...

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Main Authors: Juliette Humeau, Allan Sauvat, Giulia Cerrato, Wei Xie, Friedemann Loos, Francesca Iannantuoni, Lucillia Bezu, Sarah Lévesque, Juliette Paillet, Jonathan Pol, Marion Leduc, Laurence Zitvogel, Hugues de Thé, Oliver Kepp, Guido Kroemer
Format: Article
Language:English
Published: Springer Nature 2020-04-01
Series:EMBO Molecular Medicine
Subjects:
dactinomycin
eIF2α phosphorylation
immunogenic cell death
transcription
translation
Online Access:https://doi.org/10.15252/emmm.201911622
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