A case of basaloid follicular hamartoma
We report a case of basaloid follicular hamartoma. A 53-year-old female patient presented with a one-year history of widespread papules on the scalp, occasionally accompanied by itching. Dermatological examination revealed numerous light brown papules, sized approximately 1~3 mm in diameter, diffuse...
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editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology
2025-07-01
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| Series: | Pifu-xingbing zhenliaoxue zazhi |
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| Online Access: | http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2025.07.010 |
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| author | REN Xinxin ZHANG Xinyan JI Shuangshuang GUO Ling |
| author_facet | REN Xinxin ZHANG Xinyan JI Shuangshuang GUO Ling |
| author_sort | REN Xinxin |
| collection | DOAJ |
| description | We report a case of basaloid follicular hamartoma. A 53-year-old female patient presented with a one-year history of widespread papules on the scalp, occasionally accompanied by itching. Dermatological examination revealed numerous light brown papules, sized approximately 1~3 mm in diameter, diffusely distributed across the scalp, with the highest density in the occipital region. Some papules had coalesced. No hypertrichosis or depressions on the palms and soles were observed. Histopathology of the skin lesion revealed irregular proliferation of basaloid cells, forming multiple cell nests composed of basaloid cells embedded within a fibrous matrix. The nests were irregular in shape, with no significant cellular atypia or evident mitotic figures. Peripheral cells were arranged in a palisading pattern, with no retraction spaces between the nests and surrounding connective tissue. Amyloid deposits were observed within the matrix. Immunohistochemistry revealed CD34 positivity in the fibrous stromal cells surrounding the tumor; Bcl-2 expression was limited to a few basal cells at the outermost layer of the lesion. Diagnosis: basaloid follicular hamartoma. The patient did not respond well to electrolysis and cryotherapy with liquid nitrogen, and the rash continued to progress. The patient is still under follow-up. |
| format | Article |
| id | doaj-art-9abf9cd75d5343f2b11c8255c9b3bb17 |
| institution | Kabale University |
| issn | 1674-8468 |
| language | zho |
| publishDate | 2025-07-01 |
| publisher | editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology |
| record_format | Article |
| series | Pifu-xingbing zhenliaoxue zazhi |
| spelling | doaj-art-9abf9cd75d5343f2b11c8255c9b3bb172025-08-20T04:02:09Zzhoeditoiral office of Journal of Diagnosis and Therapy on Dermato-venereologyPifu-xingbing zhenliaoxue zazhi1674-84682025-07-0132753053310.3969/j.issn.1674-8468.2025.07.010A case of basaloid follicular hamartomaREN Xinxin0ZHANG Xinyan1JI Shuangshuang2GUO Ling3Liaocheng People′s Hospital, Liaocheng 252000, ChinaLiaocheng People′s Hospital, Liaocheng 252000, ChinaLiaocheng People′s Hospital, Liaocheng 252000, ChinaLiaocheng People′s Hospital, Liaocheng 252000, ChinaWe report a case of basaloid follicular hamartoma. A 53-year-old female patient presented with a one-year history of widespread papules on the scalp, occasionally accompanied by itching. Dermatological examination revealed numerous light brown papules, sized approximately 1~3 mm in diameter, diffusely distributed across the scalp, with the highest density in the occipital region. Some papules had coalesced. No hypertrichosis or depressions on the palms and soles were observed. Histopathology of the skin lesion revealed irregular proliferation of basaloid cells, forming multiple cell nests composed of basaloid cells embedded within a fibrous matrix. The nests were irregular in shape, with no significant cellular atypia or evident mitotic figures. Peripheral cells were arranged in a palisading pattern, with no retraction spaces between the nests and surrounding connective tissue. Amyloid deposits were observed within the matrix. Immunohistochemistry revealed CD34 positivity in the fibrous stromal cells surrounding the tumor; Bcl-2 expression was limited to a few basal cells at the outermost layer of the lesion. Diagnosis: basaloid follicular hamartoma. The patient did not respond well to electrolysis and cryotherapy with liquid nitrogen, and the rash continued to progress. The patient is still under follow-up.http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2025.07.010follicular hamartomabasaloid |
| spellingShingle | REN Xinxin ZHANG Xinyan JI Shuangshuang GUO Ling A case of basaloid follicular hamartoma Pifu-xingbing zhenliaoxue zazhi follicular hamartoma basaloid |
| title | A case of basaloid follicular hamartoma |
| title_full | A case of basaloid follicular hamartoma |
| title_fullStr | A case of basaloid follicular hamartoma |
| title_full_unstemmed | A case of basaloid follicular hamartoma |
| title_short | A case of basaloid follicular hamartoma |
| title_sort | case of basaloid follicular hamartoma |
| topic | follicular hamartoma basaloid |
| url | http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2025.07.010 |
| work_keys_str_mv | AT renxinxin acaseofbasaloidfollicularhamartoma AT zhangxinyan acaseofbasaloidfollicularhamartoma AT jishuangshuang acaseofbasaloidfollicularhamartoma AT guoling acaseofbasaloidfollicularhamartoma AT renxinxin caseofbasaloidfollicularhamartoma AT zhangxinyan caseofbasaloidfollicularhamartoma AT jishuangshuang caseofbasaloidfollicularhamartoma AT guoling caseofbasaloidfollicularhamartoma |