HLAs in children with minimal change disease and other types of nephrotic syndrome in the southern part of Turkey
The aim of this study was to investigate the human leukocyte antigen (HLA) profile of children with nephrotic syndrome in the southern part of Turkey. Seventy-eight children with nephrotic syndrome were studied for the frequency of class I and class II human leukocyte antigens. Forty-seven of...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2001-01-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/3011 |
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| author | A Karabay-Bayazit A Noyan Y Bayazit A Ozel A Anarat |
| author_facet | A Karabay-Bayazit A Noyan Y Bayazit A Ozel A Anarat |
| author_sort | A Karabay-Bayazit |
| collection | DOAJ |
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The aim of this study was to investigate the human leukocyte antigen (HLA) profile of children with nephrotic syndrome in the southern part of Turkey. Seventy-eight children with nephrotic syndrome were studied for the frequency of class I and class II human leukocyte antigens. Forty-seven of them were steroid sensitive nephrotic syndrome (minimal change disease-MCD) and 31 were other types of nephrotic syndrome. The results were compared with 133 healthy subjects for HLA groups. HLA B13, Cw5, Cw7, DR4, DR7, DRw10, Drw15(2) and DQ2 in the MCD group and HLA A31, B8, B13, B17, Cw2, Cw6, Cw7, DRw10 and DRw12 in the non-MCD group were found significantly increased when compared to healthy controls. MCD patients with frequent relapses had higher frequencies of both Cw6 and DR1 (p < 0.005) and MCD patients with infrequent relapses had a higher frequency of Cw7 (p < 0.05). In conclusion, HLA groups may help in the early diagnosis of these variants.
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| format | Article |
| id | doaj-art-9abe5d834f6f4c1da0b0cfe4d953ef43 |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2001-01-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-9abe5d834f6f4c1da0b0cfe4d953ef432025-08-20T02:58:14ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212001-01-01431HLAs in children with minimal change disease and other types of nephrotic syndrome in the southern part of TurkeyA Karabay-Bayazit0A NoyanY BayazitA OzelA AnaratDepartment of Pediatrics, Cukurova University Faculty of Medicine, Adana, Turkey. The aim of this study was to investigate the human leukocyte antigen (HLA) profile of children with nephrotic syndrome in the southern part of Turkey. Seventy-eight children with nephrotic syndrome were studied for the frequency of class I and class II human leukocyte antigens. Forty-seven of them were steroid sensitive nephrotic syndrome (minimal change disease-MCD) and 31 were other types of nephrotic syndrome. The results were compared with 133 healthy subjects for HLA groups. HLA B13, Cw5, Cw7, DR4, DR7, DRw10, Drw15(2) and DQ2 in the MCD group and HLA A31, B8, B13, B17, Cw2, Cw6, Cw7, DRw10 and DRw12 in the non-MCD group were found significantly increased when compared to healthy controls. MCD patients with frequent relapses had higher frequencies of both Cw6 and DR1 (p < 0.005) and MCD patients with infrequent relapses had a higher frequency of Cw7 (p < 0.05). In conclusion, HLA groups may help in the early diagnosis of these variants. https://turkjpediatr.org/article/view/3011 |
| spellingShingle | A Karabay-Bayazit A Noyan Y Bayazit A Ozel A Anarat HLAs in children with minimal change disease and other types of nephrotic syndrome in the southern part of Turkey The Turkish Journal of Pediatrics |
| title | HLAs in children with minimal change disease and other types of nephrotic syndrome in the southern part of Turkey |
| title_full | HLAs in children with minimal change disease and other types of nephrotic syndrome in the southern part of Turkey |
| title_fullStr | HLAs in children with minimal change disease and other types of nephrotic syndrome in the southern part of Turkey |
| title_full_unstemmed | HLAs in children with minimal change disease and other types of nephrotic syndrome in the southern part of Turkey |
| title_short | HLAs in children with minimal change disease and other types of nephrotic syndrome in the southern part of Turkey |
| title_sort | hlas in children with minimal change disease and other types of nephrotic syndrome in the southern part of turkey |
| url | https://turkjpediatr.org/article/view/3011 |
| work_keys_str_mv | AT akarabaybayazit hlasinchildrenwithminimalchangediseaseandothertypesofnephroticsyndromeinthesouthernpartofturkey AT anoyan hlasinchildrenwithminimalchangediseaseandothertypesofnephroticsyndromeinthesouthernpartofturkey AT ybayazit hlasinchildrenwithminimalchangediseaseandothertypesofnephroticsyndromeinthesouthernpartofturkey AT aozel hlasinchildrenwithminimalchangediseaseandothertypesofnephroticsyndromeinthesouthernpartofturkey AT aanarat hlasinchildrenwithminimalchangediseaseandothertypesofnephroticsyndromeinthesouthernpartofturkey |