Physical activity and lung cancer screening (PALS): feasibility randomised controlled trial of exercise and physical activity in lung cancer screening
Abstract Background There is increasing evidence that screening provides a catalyst for behavioural change. Low physical activity (PA) levels are a potentially modifiable risk factor for developing lung cancer. This study aims to assess the feasibility and safety of a semi-supervised 8-week multi-mo...
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| Language: | English |
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BMC
2025-03-01
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| Series: | Respiratory Research |
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| Online Access: | https://doi.org/10.1186/s12931-025-03158-0 |
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| author | Asha Bonney Catherine L. Granger Daniel Steinfort Cameron Patrick Henry M. Marshall Kwun M. Fong Renee Manser |
| author_facet | Asha Bonney Catherine L. Granger Daniel Steinfort Cameron Patrick Henry M. Marshall Kwun M. Fong Renee Manser |
| author_sort | Asha Bonney |
| collection | DOAJ |
| description | Abstract Background There is increasing evidence that screening provides a catalyst for behavioural change. Low physical activity (PA) levels are a potentially modifiable risk factor for developing lung cancer. This study aims to assess the feasibility and safety of a semi-supervised 8-week multi-modal exercise program to improve health-related quality of life and PA levels of participants of lung cancer screening. Methods Participants without lung cancer from a single Australian International Lung Screen Trial (ILST; NCT02871856) site were invited to this feasibility randomised controlled trial. Enrolled participants were randomised to usual care, written material, or a home-based exercise program (in addition to written material). Assessments occurred at baseline, 9 weeks, and 6 months. Results 75 participants were enrolled over a 3-month period in 2022 (consent rate of 67%). 43% of participants were female, median age 66 years old (IQR 62, 73). Of the 25 participants randomised to the home-based exercise program, 22 participants (88%) attended > 70% of weekly sessions. 99% (74/75) of study participants attended their 9-week and 6-month follow-up assessments. Conclusions This study confirms the feasibility and high compliance of delivering a semi-supervised 8-week multi-modal exercise program to participants of a lung cancer screening program. It was safe, with no adverse events. Clinical trial registration Australian Clinical Trials Register https://www.australianclinicaltrials.gov.au ACTRN12622001001785. |
| format | Article |
| id | doaj-art-9ab9807fb131479b8ce10176f4355bfe |
| institution | DOAJ |
| issn | 1465-993X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj-art-9ab9807fb131479b8ce10176f4355bfe2025-08-20T03:05:45ZengBMCRespiratory Research1465-993X2025-03-012611910.1186/s12931-025-03158-0Physical activity and lung cancer screening (PALS): feasibility randomised controlled trial of exercise and physical activity in lung cancer screeningAsha Bonney0Catherine L. Granger1Daniel Steinfort2Cameron Patrick3Henry M. Marshall4Kwun M. Fong5Renee Manser6Department of Medicine, University of MelbourneDepartment of Physiotherapy, The Royal Melbourne HospitalDepartment of Medicine, University of MelbourneStatistical Consulting Centre, School of Mathematics and Statistics, The University of MelbourneThoracic Research Centre, The University of QueenslandThoracic Research Centre, The University of QueenslandDepartment of Medicine, University of MelbourneAbstract Background There is increasing evidence that screening provides a catalyst for behavioural change. Low physical activity (PA) levels are a potentially modifiable risk factor for developing lung cancer. This study aims to assess the feasibility and safety of a semi-supervised 8-week multi-modal exercise program to improve health-related quality of life and PA levels of participants of lung cancer screening. Methods Participants without lung cancer from a single Australian International Lung Screen Trial (ILST; NCT02871856) site were invited to this feasibility randomised controlled trial. Enrolled participants were randomised to usual care, written material, or a home-based exercise program (in addition to written material). Assessments occurred at baseline, 9 weeks, and 6 months. Results 75 participants were enrolled over a 3-month period in 2022 (consent rate of 67%). 43% of participants were female, median age 66 years old (IQR 62, 73). Of the 25 participants randomised to the home-based exercise program, 22 participants (88%) attended > 70% of weekly sessions. 99% (74/75) of study participants attended their 9-week and 6-month follow-up assessments. Conclusions This study confirms the feasibility and high compliance of delivering a semi-supervised 8-week multi-modal exercise program to participants of a lung cancer screening program. It was safe, with no adverse events. Clinical trial registration Australian Clinical Trials Register https://www.australianclinicaltrials.gov.au ACTRN12622001001785.https://doi.org/10.1186/s12931-025-03158-0ExerciseLung cancerPreventionScreening |
| spellingShingle | Asha Bonney Catherine L. Granger Daniel Steinfort Cameron Patrick Henry M. Marshall Kwun M. Fong Renee Manser Physical activity and lung cancer screening (PALS): feasibility randomised controlled trial of exercise and physical activity in lung cancer screening Respiratory Research Exercise Lung cancer Prevention Screening |
| title | Physical activity and lung cancer screening (PALS): feasibility randomised controlled trial of exercise and physical activity in lung cancer screening |
| title_full | Physical activity and lung cancer screening (PALS): feasibility randomised controlled trial of exercise and physical activity in lung cancer screening |
| title_fullStr | Physical activity and lung cancer screening (PALS): feasibility randomised controlled trial of exercise and physical activity in lung cancer screening |
| title_full_unstemmed | Physical activity and lung cancer screening (PALS): feasibility randomised controlled trial of exercise and physical activity in lung cancer screening |
| title_short | Physical activity and lung cancer screening (PALS): feasibility randomised controlled trial of exercise and physical activity in lung cancer screening |
| title_sort | physical activity and lung cancer screening pals feasibility randomised controlled trial of exercise and physical activity in lung cancer screening |
| topic | Exercise Lung cancer Prevention Screening |
| url | https://doi.org/10.1186/s12931-025-03158-0 |
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