Immune cell profiling of the ICAM1 p.K56M heart failure with preserved ejection fraction risk variant

Immune cell profiling of the ICAM1 p.K56M heart failure with preserved ejection fraction risk variant

Abstract Aims Intercellular adhesion molecule‐1 (ICAM‐1) facilitates inflammation via leucocyte recruitment and has been implicated in heart failure with preserved ejection fraction (HFpEF). Approximately 35% of African American individuals carry a copy of an ICAM1 missense variant (rs5491; p.K56M),...

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Main Authors: Jing Gao, Pedro Giro, Joseph A. Delaney, Laura Rasmussen‐Torvik, Kent D. Taylor, Edward B. Thorp, Margaret F. Doyle, Matthew J. Feinstein, Colleen M. Sitlani, Nels Olson, Russell Tracy, Sanjiv J. Shah, Bruce M. Psaty, Ravi B. Patel
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:ESC Heart Failure
Subjects:
echocardiography
genetics
heart failure with preserved ejection fraction
immune cells
intercellular adhesion molecule‐1
Online Access:https://doi.org/10.1002/ehf2.14983
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