Amorphous Extracellular Eosinophilic Material – The Diagnostic Challenge in Histopathology
Amyloidosis encompasses a diverse group of conditions characterized by the extracellular accumulation of misfolded, insoluble proteinaceous material with a cross-beta-pleated sheet structure, leading to organ damage. Due to its varied origins and manifestations, different diagnostic tools are requir...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Current Medical Issues |
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| Online Access: | https://journals.lww.com/10.4103/cmi.cmi_108_24 |
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| author | P. Sivakumar P. Rajkumar S. K. Sridevi L. Priyadharshini M. Elancheran |
| author_facet | P. Sivakumar P. Rajkumar S. K. Sridevi L. Priyadharshini M. Elancheran |
| author_sort | P. Sivakumar |
| collection | DOAJ |
| description | Amyloidosis encompasses a diverse group of conditions characterized by the extracellular accumulation of misfolded, insoluble proteinaceous material with a cross-beta-pleated sheet structure, leading to organ damage. Due to its varied origins and manifestations, different diagnostic tools are required for accurate diagnosis. A definitive diagnosis is achieved through biopsy, revealing amyloid deposits in the affected tissue. When stained with hematoxylin and eosin, amyloid material appears as amorphous eosinophilic acellular deposits. These morphological features are shared with other substances such as collagen, fibrin, plasma, hyaline globules, hyalinization, and necrosis, posing a diagnostic challenge for pathologists. However, morphology, surrounding tissue morphology, and special stains can differentiate between amyloid and amyloid-like material. This case series of six cases highlights the appropriate staining techniques for differentiating amyloid from amyloid-like material in histopathology. |
| format | Article |
| id | doaj-art-9ab46189f03342b3a499578eb6a728aa |
| institution | Kabale University |
| issn | 0973-4651 2666-4054 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Current Medical Issues |
| spelling | doaj-art-9ab46189f03342b3a499578eb6a728aa2025-02-10T14:49:48ZengWolters Kluwer Medknow PublicationsCurrent Medical Issues0973-46512666-40542025-01-01231707410.4103/cmi.cmi_108_24Amorphous Extracellular Eosinophilic Material – The Diagnostic Challenge in HistopathologyP. SivakumarP. RajkumarS. K. SrideviL. PriyadharshiniM. ElancheranAmyloidosis encompasses a diverse group of conditions characterized by the extracellular accumulation of misfolded, insoluble proteinaceous material with a cross-beta-pleated sheet structure, leading to organ damage. Due to its varied origins and manifestations, different diagnostic tools are required for accurate diagnosis. A definitive diagnosis is achieved through biopsy, revealing amyloid deposits in the affected tissue. When stained with hematoxylin and eosin, amyloid material appears as amorphous eosinophilic acellular deposits. These morphological features are shared with other substances such as collagen, fibrin, plasma, hyaline globules, hyalinization, and necrosis, posing a diagnostic challenge for pathologists. However, morphology, surrounding tissue morphology, and special stains can differentiate between amyloid and amyloid-like material. This case series of six cases highlights the appropriate staining techniques for differentiating amyloid from amyloid-like material in histopathology.https://journals.lww.com/10.4103/cmi.cmi_108_24amyloid-like materialamyloidosiscongo red staininghistopathology |
| spellingShingle | P. Sivakumar P. Rajkumar S. K. Sridevi L. Priyadharshini M. Elancheran Amorphous Extracellular Eosinophilic Material – The Diagnostic Challenge in Histopathology Current Medical Issues amyloid-like material amyloidosis congo red staining histopathology |
| title | Amorphous Extracellular Eosinophilic Material – The Diagnostic Challenge in Histopathology |
| title_full | Amorphous Extracellular Eosinophilic Material – The Diagnostic Challenge in Histopathology |
| title_fullStr | Amorphous Extracellular Eosinophilic Material – The Diagnostic Challenge in Histopathology |
| title_full_unstemmed | Amorphous Extracellular Eosinophilic Material – The Diagnostic Challenge in Histopathology |
| title_short | Amorphous Extracellular Eosinophilic Material – The Diagnostic Challenge in Histopathology |
| title_sort | amorphous extracellular eosinophilic material the diagnostic challenge in histopathology |
| topic | amyloid-like material amyloidosis congo red staining histopathology |
| url | https://journals.lww.com/10.4103/cmi.cmi_108_24 |
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