Outcome of Ahmed glaucoma valve implant in congenital fibrovascular pupillary membrane with secondary glaucoma
Abstract Background Congenital fibrovascular pupillary membranes in secondary glaucoma (CFPMSG) is kind of refractory childhood glaucoma. The aim of the study is to evaluate the efficacy and safety of Ahmed glaucoma valve (AGV) implants in CFPMSG. Methods Twelve patients with CFPMSG who underwent an...
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2025-03-01
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| Online Access: | https://doi.org/10.1186/s12886-025-03980-6 |
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| author | Yingting Zhu Shufen Lin Lei Fang Liming Chen Pingping Liu Yimin Zhong Xing Liu |
| author_facet | Yingting Zhu Shufen Lin Lei Fang Liming Chen Pingping Liu Yimin Zhong Xing Liu |
| author_sort | Yingting Zhu |
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| description | Abstract Background Congenital fibrovascular pupillary membranes in secondary glaucoma (CFPMSG) is kind of refractory childhood glaucoma. The aim of the study is to evaluate the efficacy and safety of Ahmed glaucoma valve (AGV) implants in CFPMSG. Methods Twelve patients with CFPMSG who underwent anterior chamber reconstruction (ASR) with a stable anterior chamber but uncontrolled intraocular pressure (IOP) underwent AGV implantation. Patients with a follow-up period of > 12 months were enrolled. Demographic data were collected. All patients underwent comprehensive ophthalmic examinations before and after surgeries, including IOP measurement, A- and B-scan ultrasonography, and ultrasound biomicroscopy (UBM), etc. Success was defined as postoperative intraocular pressure (IOP) ≤ 21 mmHg with (qualified success) or without (complete success) the use of glaucoma drugs. Results The median age of enrolled patients was 15.1 ± 12.5 months old (range 4.5–46) and 58.3% of them were female. At last follow-up (32.0 ± 16.0 months), the average IOP was declined (postoperative: 18.7 ± 4.5 mmHg vs. preoperative: 29.0 ± 4.0 mmHg, p < 0.001). The number of glaucoma drugs decreased from 3 (range 2–3) to 1.5 (range 0–3) (P < 0.001), while the anterior chamber depth (ACD) remained stable (3.21 ± 0.70 mm and 3.40 ± 0.82 mm, respectively) (p = 0.57) after AGV implantation. The complete success rate was 25% (3/12) and the qualified success rate was 58.3% (7/12). The total success rate was 83.8%. No severe complications were noted. Conclusions This study demonstrated that AGV implants could be safe and effective for CFPMSG with uncontrolled IOP. AGV implantation is a feasible option for the treatment of CFPMSG. |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-03-01 |
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| series | BMC Ophthalmology |
| spelling | doaj-art-9ab35ac2f00048aabf094e5e0f601c112025-08-20T03:40:47ZengBMCBMC Ophthalmology1471-24152025-03-012511710.1186/s12886-025-03980-6Outcome of Ahmed glaucoma valve implant in congenital fibrovascular pupillary membrane with secondary glaucomaYingting Zhu0Shufen Lin1Lei Fang2Liming Chen3Pingping Liu4Yimin Zhong5Xing Liu6State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Provincial Clinical Research Center for Ocular Diseases, Sun Yat-sen UniversityState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Provincial Clinical Research Center for Ocular Diseases, Sun Yat-sen UniversityState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Provincial Clinical Research Center for Ocular Diseases, Sun Yat-sen UniversityState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Provincial Clinical Research Center for Ocular Diseases, Sun Yat-sen UniversityState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Provincial Clinical Research Center for Ocular Diseases, Sun Yat-sen UniversityState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Provincial Clinical Research Center for Ocular Diseases, Sun Yat-sen UniversityState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Provincial Clinical Research Center for Ocular Diseases, Sun Yat-sen UniversityAbstract Background Congenital fibrovascular pupillary membranes in secondary glaucoma (CFPMSG) is kind of refractory childhood glaucoma. The aim of the study is to evaluate the efficacy and safety of Ahmed glaucoma valve (AGV) implants in CFPMSG. Methods Twelve patients with CFPMSG who underwent anterior chamber reconstruction (ASR) with a stable anterior chamber but uncontrolled intraocular pressure (IOP) underwent AGV implantation. Patients with a follow-up period of > 12 months were enrolled. Demographic data were collected. All patients underwent comprehensive ophthalmic examinations before and after surgeries, including IOP measurement, A- and B-scan ultrasonography, and ultrasound biomicroscopy (UBM), etc. Success was defined as postoperative intraocular pressure (IOP) ≤ 21 mmHg with (qualified success) or without (complete success) the use of glaucoma drugs. Results The median age of enrolled patients was 15.1 ± 12.5 months old (range 4.5–46) and 58.3% of them were female. At last follow-up (32.0 ± 16.0 months), the average IOP was declined (postoperative: 18.7 ± 4.5 mmHg vs. preoperative: 29.0 ± 4.0 mmHg, p < 0.001). The number of glaucoma drugs decreased from 3 (range 2–3) to 1.5 (range 0–3) (P < 0.001), while the anterior chamber depth (ACD) remained stable (3.21 ± 0.70 mm and 3.40 ± 0.82 mm, respectively) (p = 0.57) after AGV implantation. The complete success rate was 25% (3/12) and the qualified success rate was 58.3% (7/12). The total success rate was 83.8%. No severe complications were noted. Conclusions This study demonstrated that AGV implants could be safe and effective for CFPMSG with uncontrolled IOP. AGV implantation is a feasible option for the treatment of CFPMSG.https://doi.org/10.1186/s12886-025-03980-6Congenital fibrovascular pupillary membraneSecondary glaucomaAhmed glaucoma valve implantation |
| spellingShingle | Yingting Zhu Shufen Lin Lei Fang Liming Chen Pingping Liu Yimin Zhong Xing Liu Outcome of Ahmed glaucoma valve implant in congenital fibrovascular pupillary membrane with secondary glaucoma BMC Ophthalmology Congenital fibrovascular pupillary membrane Secondary glaucoma Ahmed glaucoma valve implantation |
| title | Outcome of Ahmed glaucoma valve implant in congenital fibrovascular pupillary membrane with secondary glaucoma |
| title_full | Outcome of Ahmed glaucoma valve implant in congenital fibrovascular pupillary membrane with secondary glaucoma |
| title_fullStr | Outcome of Ahmed glaucoma valve implant in congenital fibrovascular pupillary membrane with secondary glaucoma |
| title_full_unstemmed | Outcome of Ahmed glaucoma valve implant in congenital fibrovascular pupillary membrane with secondary glaucoma |
| title_short | Outcome of Ahmed glaucoma valve implant in congenital fibrovascular pupillary membrane with secondary glaucoma |
| title_sort | outcome of ahmed glaucoma valve implant in congenital fibrovascular pupillary membrane with secondary glaucoma |
| topic | Congenital fibrovascular pupillary membrane Secondary glaucoma Ahmed glaucoma valve implantation |
| url | https://doi.org/10.1186/s12886-025-03980-6 |
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