Protein carbamylation in atherosclerotic plaques correlates with uremia and disease progression, localizing predominantly to foam cells

Protein carbamylation in atherosclerotic plaques correlates with uremia and disease progression, localizing predominantly to foam cells

IntroductionCarbamylation is a non-enzymatic post-translational protein modification common in patients with uremia that causes pro-atherogenic alterations in plasma proteins. It is abundantly present in late-stage atherosclerotic plaques; however, the pathogenic relevance and functional consequence...

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Main Authors: Valeria Saar-Kovrov, Aleksandra Pawlowska, Adrien Guillot, Marion J. J. Gijbels, Judith C. Sluimer, Lieve Temmerman, Pieter Goossens, Barend M. E. Mees, Frank Tacke, Vera Jankowski, Joachim Jankowski, Marjo M. P. C. Donners, Erik A. L. Biessen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
atherosclerosis
macrophages
foam cells
carbamylation
kidney disease
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1532250/full
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