The dysfunction of complement and coagulation in diseases: the implications for the therapeutic interventions
Abstract The complement system, comprising over 30 proteins, is integral to the immune system, and the coagulation system is critical for vascular homeostasis. The activation of the complement and coagulation systems involves an organized proteolytic cascade, and the overactivation of these systems...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-11-01
|
| Series: | MedComm |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/mco2.785 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846167472325001216 |
|---|---|
| author | Honghong Jiang Yiming Guo Qihang Wang Yiran Wang Dingchuan Peng Yigong Fang Lei Yan Zhuolin Ruan Sheng Zhang Yong Zhao Wendan Zhang Wei Shang Zhichun Feng |
| author_facet | Honghong Jiang Yiming Guo Qihang Wang Yiran Wang Dingchuan Peng Yigong Fang Lei Yan Zhuolin Ruan Sheng Zhang Yong Zhao Wendan Zhang Wei Shang Zhichun Feng |
| author_sort | Honghong Jiang |
| collection | DOAJ |
| description | Abstract The complement system, comprising over 30 proteins, is integral to the immune system, and the coagulation system is critical for vascular homeostasis. The activation of the complement and coagulation systems involves an organized proteolytic cascade, and the overactivation of these systems is a central pathogenic mechanism in several diseases. This review describes the role of complement and coagulation system activation in critical illness, particularly sepsis. The complexities of sepsis reveal significant knowledge gaps that can be compared to a profound abyss, highlighting the urgent need for further investigation and exploration. It is well recognized that the inflammatory network, coagulation, and complement systems are integral mechanisms through which multiple factors contribute to increased susceptibility to infection and may result in a disordered immune response during septic events in patients. Given the overlapping pathogenic mechanisms in sepsis, immunomodulatory therapies currently under development may be particularly beneficial for patients with sepsis who have concurrent infections. Herein, we present recent findings regarding the molecular relationships between the coagulation and complement pathways in the advancement of sepsis, and propose potential intervention targets related to the crosstalk between coagulation and complement, aiming to provide more valuable treatment of sepsis. |
| format | Article |
| id | doaj-art-9aa51146aadd4f388918624762d88ca7 |
| institution | Kabale University |
| issn | 2688-2663 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm |
| spelling | doaj-art-9aa51146aadd4f388918624762d88ca72024-11-14T16:14:36ZengWileyMedComm2688-26632024-11-01511n/an/a10.1002/mco2.785The dysfunction of complement and coagulation in diseases: the implications for the therapeutic interventionsHonghong Jiang0Yiming Guo1Qihang Wang2Yiran Wang3Dingchuan Peng4Yigong Fang5Lei Yan6Zhuolin Ruan7Sheng Zhang8Yong Zhao9Wendan Zhang10Wei Shang11Zhichun Feng12Faculty of Pediatrics, the Seventh Medical Center of Chinese PLA General HospitalNational Engineering Laboratory for Birth Defects Prevention and Control of Key Technology, Beijing Key Laboratory of Pediatric Organ FailureBeijingChinaDepartment of Biological Science, The Dietrich School of Arts and SciencesUniversity of PittsburghPittsburghPennsylvaniaUSADepartment of Obstetrics and GynecologyThe Seventh Medical Center of Chinese PLA General HospitalBeijingChinaDepartment of Obstetrics and GynecologyThe sixth Medical Center of Chinese PLA General HospitalBeijingChinaSchool of MedicineSouth China University of TechnologyGuangzhouChinaInstitute of Acupuncture and MoxibustionChina Academy of Chinese Medical SciencesBeijingChinaFaculty of Pediatrics, the Seventh Medical Center of Chinese PLA General HospitalNational Engineering Laboratory for Birth Defects Prevention and Control of Key Technology, Beijing Key Laboratory of Pediatric Organ FailureBeijingChinaDepartment of Obstetrics and Gynecology，Chinese PLA General HospitalBeijing ChinaFaculty of Pediatrics, the Seventh Medical Center of Chinese PLA General HospitalNational Engineering Laboratory for Birth Defects Prevention and Control of Key Technology, Beijing Key Laboratory of Pediatric Organ FailureBeijingChinaDepartment of Obstetrics and GynecologyThe Seventh Medical Center of Chinese PLA General HospitalBeijingChinaFaculty of Pediatrics, the Seventh Medical Center of Chinese PLA General HospitalNational Engineering Laboratory for Birth Defects Prevention and Control of Key Technology, Beijing Key Laboratory of Pediatric Organ FailureBeijingChinaFaculty of Pediatrics, the Seventh Medical Center of Chinese PLA General HospitalNational Engineering Laboratory for Birth Defects Prevention and Control of Key Technology, Beijing Key Laboratory of Pediatric Organ FailureBeijingChinaFaculty of Pediatrics, the Seventh Medical Center of Chinese PLA General HospitalNational Engineering Laboratory for Birth Defects Prevention and Control of Key Technology, Beijing Key Laboratory of Pediatric Organ FailureBeijingChinaAbstract The complement system, comprising over 30 proteins, is integral to the immune system, and the coagulation system is critical for vascular homeostasis. The activation of the complement and coagulation systems involves an organized proteolytic cascade, and the overactivation of these systems is a central pathogenic mechanism in several diseases. This review describes the role of complement and coagulation system activation in critical illness, particularly sepsis. The complexities of sepsis reveal significant knowledge gaps that can be compared to a profound abyss, highlighting the urgent need for further investigation and exploration. It is well recognized that the inflammatory network, coagulation, and complement systems are integral mechanisms through which multiple factors contribute to increased susceptibility to infection and may result in a disordered immune response during septic events in patients. Given the overlapping pathogenic mechanisms in sepsis, immunomodulatory therapies currently under development may be particularly beneficial for patients with sepsis who have concurrent infections. Herein, we present recent findings regarding the molecular relationships between the coagulation and complement pathways in the advancement of sepsis, and propose potential intervention targets related to the crosstalk between coagulation and complement, aiming to provide more valuable treatment of sepsis.https://doi.org/10.1002/mco2.785coagulationcomplement systemimmune responseinflammatory networksepsis |
| spellingShingle | Honghong Jiang Yiming Guo Qihang Wang Yiran Wang Dingchuan Peng Yigong Fang Lei Yan Zhuolin Ruan Sheng Zhang Yong Zhao Wendan Zhang Wei Shang Zhichun Feng The dysfunction of complement and coagulation in diseases: the implications for the therapeutic interventions MedComm coagulation complement system immune response inflammatory network sepsis |
| title | The dysfunction of complement and coagulation in diseases: the implications for the therapeutic interventions |
| title_full | The dysfunction of complement and coagulation in diseases: the implications for the therapeutic interventions |
| title_fullStr | The dysfunction of complement and coagulation in diseases: the implications for the therapeutic interventions |
| title_full_unstemmed | The dysfunction of complement and coagulation in diseases: the implications for the therapeutic interventions |
| title_short | The dysfunction of complement and coagulation in diseases: the implications for the therapeutic interventions |
| title_sort | dysfunction of complement and coagulation in diseases the implications for the therapeutic interventions |
| topic | coagulation complement system immune response inflammatory network sepsis |
| url | https://doi.org/10.1002/mco2.785 |
| work_keys_str_mv | AT honghongjiang thedysfunctionofcomplementandcoagulationindiseasestheimplicationsforthetherapeuticinterventions AT yimingguo thedysfunctionofcomplementandcoagulationindiseasestheimplicationsforthetherapeuticinterventions AT qihangwang thedysfunctionofcomplementandcoagulationindiseasestheimplicationsforthetherapeuticinterventions AT yiranwang thedysfunctionofcomplementandcoagulationindiseasestheimplicationsforthetherapeuticinterventions AT dingchuanpeng thedysfunctionofcomplementandcoagulationindiseasestheimplicationsforthetherapeuticinterventions AT yigongfang thedysfunctionofcomplementandcoagulationindiseasestheimplicationsforthetherapeuticinterventions AT leiyan thedysfunctionofcomplementandcoagulationindiseasestheimplicationsforthetherapeuticinterventions AT zhuolinruan thedysfunctionofcomplementandcoagulationindiseasestheimplicationsforthetherapeuticinterventions AT shengzhang thedysfunctionofcomplementandcoagulationindiseasestheimplicationsforthetherapeuticinterventions AT yongzhao thedysfunctionofcomplementandcoagulationindiseasestheimplicationsforthetherapeuticinterventions AT wendanzhang thedysfunctionofcomplementandcoagulationindiseasestheimplicationsforthetherapeuticinterventions AT weishang thedysfunctionofcomplementandcoagulationindiseasestheimplicationsforthetherapeuticinterventions AT zhichunfeng thedysfunctionofcomplementandcoagulationindiseasestheimplicationsforthetherapeuticinterventions AT honghongjiang dysfunctionofcomplementandcoagulationindiseasestheimplicationsforthetherapeuticinterventions AT yimingguo dysfunctionofcomplementandcoagulationindiseasestheimplicationsforthetherapeuticinterventions AT qihangwang dysfunctionofcomplementandcoagulationindiseasestheimplicationsforthetherapeuticinterventions AT yiranwang dysfunctionofcomplementandcoagulationindiseasestheimplicationsforthetherapeuticinterventions AT dingchuanpeng dysfunctionofcomplementandcoagulationindiseasestheimplicationsforthetherapeuticinterventions AT yigongfang dysfunctionofcomplementandcoagulationindiseasestheimplicationsforthetherapeuticinterventions AT leiyan dysfunctionofcomplementandcoagulationindiseasestheimplicationsforthetherapeuticinterventions AT zhuolinruan dysfunctionofcomplementandcoagulationindiseasestheimplicationsforthetherapeuticinterventions AT shengzhang dysfunctionofcomplementandcoagulationindiseasestheimplicationsforthetherapeuticinterventions AT yongzhao dysfunctionofcomplementandcoagulationindiseasestheimplicationsforthetherapeuticinterventions AT wendanzhang dysfunctionofcomplementandcoagulationindiseasestheimplicationsforthetherapeuticinterventions AT weishang dysfunctionofcomplementandcoagulationindiseasestheimplicationsforthetherapeuticinterventions AT zhichunfeng dysfunctionofcomplementandcoagulationindiseasestheimplicationsforthetherapeuticinterventions |