Differential effects of antiemetic serotonin receptor antagonist Ondansetron on nausea associated with CHRM3 rs2165870 and TACR1 rs3755468 single-nucleotide polymorphisms

Differential effects of antiemetic serotonin receptor antagonist Ondansetron on nausea associated with CHRM3 rs2165870 and TACR1 rs3755468 single-nucleotide polymorphisms

Abstract Postoperative nausea and vomiting (PONV) after orthognathic surgery is a serious postoperative complication. The cholinergic receptor muscarinic 3 (CHRM3) rs2165870 and tachykinin receptor 1 (TACR1) rs3755468 single-nucleotide polymorphisms (SNPs) have been reported to be involved in PONV....

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Bibliographic Details
Main Authors: Yuna Kang, Seii Ohka, Daisuke Nishizawa, Junko Hasegawa, Kyoko Nakayama, Kaori Yoshida, Kyotaro Koshika, Tatsuya Ichinohe, Kazutaka Ikeda
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Molecular Brain
Subjects:
PONV
Nausea
Orthognathic surgery
Ondansetron
SNP
Online Access:https://doi.org/10.1186/s13041-025-01237-3
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