Synthesis, antimycobacterial and antifungal evaluation of new 4-(furan-2-ylmethyl)-6-methylpyridazin-3(2H)-ones
This study reports the synthesis and evaluation of a series of new pyridazin-3-ones with furan moieties 5a–j and 6a–f, to test for their antimycobacterial and antifungal activities. The structures of the target compounds were confirmed by elemental analysis and spectroscopic techniques (IR, mass, 1H...
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| Format: | Article |
| Language: | English |
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Serbian Chemical Society
2024-01-01
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| Series: | Journal of the Serbian Chemical Society |
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| Online Access: | https://doiserbia.nb.rs/img/doi/0352-5139/2024/0352-51392400040K.pdf |
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| author | Karayavuz Burcu Vagolu Siva Krishna Kart Didem Tønjum Tone Unsal-Tan Oya |
| author_facet | Karayavuz Burcu Vagolu Siva Krishna Kart Didem Tønjum Tone Unsal-Tan Oya |
| author_sort | Karayavuz Burcu |
| collection | DOAJ |
| description | This study reports the synthesis and evaluation of a series of new pyridazin-3-ones with furan moieties 5a–j and 6a–f, to test for their antimycobacterial and antifungal activities. The structures of the target compounds were confirmed by elemental analysis and spectroscopic techniques (IR, mass, 1H-and 13C-NMR). Amongst the compounds tested, 5e, 5g, 5i and 6e exhibited highest activity against Mycobacterium tuberculosis, while 5h, 6d and 6f showed moderate in vitro antifungal activities against Candida albicans and Candida parapsilosis. |
| format | Article |
| id | doaj-art-9a90ec95f4eb4e6586c36aa6f4daf2c1 |
| institution | Kabale University |
| issn | 0352-5139 1820-7421 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj-art-9a90ec95f4eb4e6586c36aa6f4daf2c12025-01-30T06:45:49ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51391820-74212024-01-0189111423143110.2298/JSC230424040K0352-51392400040KSynthesis, antimycobacterial and antifungal evaluation of new 4-(furan-2-ylmethyl)-6-methylpyridazin-3(2H)-onesKarayavuz Burcu0Vagolu Siva Krishna1Kart Didem2Tønjum Tone3https://orcid.org/0000-0002-1709-6921Unsal-Tan Oya4https://orcid.org/0000-0002-4152-069XDepartment of Pharmaceutical Chemistry, Faculty of Farmacy, Hacettepe University, Ankara, TurkeyUnit for Genome Dynamics, Department of Microbiology, University of Oslo, Oslo, NorwayDepartment of Pharmaceutical Microbiology, Faculty of Pharmacy, Hacettepe University, Ankara, TurkeyUnit for Genome Dynamics, Department of Microbiology, University of Oslo, Oslo, Norway + Unit for Genome Dynamics, Department of Microbiology, Oslo University Hospital, Oslo, NorwayDepartment of Pharmaceutical Chemistry, Faculty of Farmacy, Hacettepe University, Ankara, TurkeyThis study reports the synthesis and evaluation of a series of new pyridazin-3-ones with furan moieties 5a–j and 6a–f, to test for their antimycobacterial and antifungal activities. The structures of the target compounds were confirmed by elemental analysis and spectroscopic techniques (IR, mass, 1H-and 13C-NMR). Amongst the compounds tested, 5e, 5g, 5i and 6e exhibited highest activity against Mycobacterium tuberculosis, while 5h, 6d and 6f showed moderate in vitro antifungal activities against Candida albicans and Candida parapsilosis.https://doiserbia.nb.rs/img/doi/0352-5139/2024/0352-51392400040K.pdfpyridazinonefuranbiological activity |
| spellingShingle | Karayavuz Burcu Vagolu Siva Krishna Kart Didem Tønjum Tone Unsal-Tan Oya Synthesis, antimycobacterial and antifungal evaluation of new 4-(furan-2-ylmethyl)-6-methylpyridazin-3(2H)-ones Journal of the Serbian Chemical Society pyridazinone furan biological activity |
| title | Synthesis, antimycobacterial and antifungal evaluation of new 4-(furan-2-ylmethyl)-6-methylpyridazin-3(2H)-ones |
| title_full | Synthesis, antimycobacterial and antifungal evaluation of new 4-(furan-2-ylmethyl)-6-methylpyridazin-3(2H)-ones |
| title_fullStr | Synthesis, antimycobacterial and antifungal evaluation of new 4-(furan-2-ylmethyl)-6-methylpyridazin-3(2H)-ones |
| title_full_unstemmed | Synthesis, antimycobacterial and antifungal evaluation of new 4-(furan-2-ylmethyl)-6-methylpyridazin-3(2H)-ones |
| title_short | Synthesis, antimycobacterial and antifungal evaluation of new 4-(furan-2-ylmethyl)-6-methylpyridazin-3(2H)-ones |
| title_sort | synthesis antimycobacterial and antifungal evaluation of new 4 furan 2 ylmethyl 6 methylpyridazin 3 2h ones |
| topic | pyridazinone furan biological activity |
| url | https://doiserbia.nb.rs/img/doi/0352-5139/2024/0352-51392400040K.pdf |
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