Gene polymorphisms of IL-1β (C511T), IL-17A (G197A), IL-12B (A1188C), TNFα (G308A) and IL-4 (C589T) associated with threat of early reproductive losses

Gene polymorphisms of IL-1β (C511T), IL-17A (G197A), IL-12B (A1188C), TNFα (G308A) and IL-4 (C589T) associated with threat of early reproductive losses

Prevalence of threatened miscarriage is 16-25% of all pregnancies. The symptomatics of the threatened miscarriage in the first trimester may develop due to conversion of initial inflammatory reaction that disturbs the intersystemic and local interactions in the endometrium, followed by placental ins...

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Bibliographic Details
Main Authors: E. A. Tatarkova, A. R. Tuguz, A. A. Tsikunib, D. S. Shumilov, I. V. Smolkov, K. A. Rudenko, D. V. Muzhenya
Format: Article
Language:Russian
Published: St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists 2020-01-01
Series:Медицинская иммунология
Subjects:
threatened miscarriage
snps of cytokine genes
il-17a (g197a
rs2275913)
il-1β (с511т
rs16944)
il-4 (c589t
rs2243250)
tnfα (g308a
rs1800629)
il-12b (a1188c
rs3212227)
Online Access:https://www.mimmun.ru/mimmun/article/view/1741
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