Genetic characterization of a new candidate hemagglutinin subtype of influenza A viruses
Avian influenza viruses (AIV) have been classified on the basis of 16 subtypes of hemagglutinin (HA) and 9 subtypes of neuraminidase. Here we describe genomic evidence for a new candidate HA subtype, nominally H19, with a large genetic distance to all previously described AIV subtypes, derived from...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Emerging Microbes and Infections |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2023.2225645 |
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| _version_ | 1849422159586263040 |
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| author | Sasan Fereidouni Elke Starick Kobey Karamendin Cecilia Di Genova Simon D. Scott Yelizaveta Khan Timm Harder Aidyn Kydyrmanov |
| author_facet | Sasan Fereidouni Elke Starick Kobey Karamendin Cecilia Di Genova Simon D. Scott Yelizaveta Khan Timm Harder Aidyn Kydyrmanov |
| author_sort | Sasan Fereidouni |
| collection | DOAJ |
| description | Avian influenza viruses (AIV) have been classified on the basis of 16 subtypes of hemagglutinin (HA) and 9 subtypes of neuraminidase. Here we describe genomic evidence for a new candidate HA subtype, nominally H19, with a large genetic distance to all previously described AIV subtypes, derived from a cloacal swab sample of a Common Pochard (Aythya ferina) in Kazakhstan, in 2008. Avian influenza monitoring in wild birds especially in migratory hotspots such as central Asia is an important approach to gain information about the circulation of known and novel influenza viruses. Genetically, the novel HA coding sequence exhibits only 68.2% nucleotide and 68.5% amino acid identity with its nearest relation in the H9 (N2) subtype. The new HA sequence should be considered in current genomic diagnostic AI assays to facilitate its detection and eventual isolation enabling further study and antigenic classification. |
| format | Article |
| id | doaj-art-9a8e1bc3623f4a10aa9fccece025c4a0 |
| institution | Kabale University |
| issn | 2222-1751 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-9a8e1bc3623f4a10aa9fccece025c4a02025-08-20T03:31:12ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512023-12-0112210.1080/22221751.2023.2225645Genetic characterization of a new candidate hemagglutinin subtype of influenza A virusesSasan Fereidouni0Elke Starick1Kobey Karamendin2Cecilia Di Genova3Simon D. Scott4Yelizaveta Khan5Timm Harder6Aidyn Kydyrmanov7Research Institute of Wildlife Ecology, University of Veterinary Medicine Vienna, Vienna, AustriaFriedrich Loeffler Institute, Insel Riems, GermanyLaboratory for Ecology of Viruses, Research and Production Center for Microbiology and Virology, Almaty, KazakhstanUniversities of Kent & Greenwich, Chatham Maritime, Kent, UKUniversities of Kent & Greenwich, Chatham Maritime, Kent, UKLaboratory for Ecology of Viruses, Research and Production Center for Microbiology and Virology, Almaty, KazakhstanFriedrich Loeffler Institute, Insel Riems, GermanyLaboratory for Ecology of Viruses, Research and Production Center for Microbiology and Virology, Almaty, KazakhstanAvian influenza viruses (AIV) have been classified on the basis of 16 subtypes of hemagglutinin (HA) and 9 subtypes of neuraminidase. Here we describe genomic evidence for a new candidate HA subtype, nominally H19, with a large genetic distance to all previously described AIV subtypes, derived from a cloacal swab sample of a Common Pochard (Aythya ferina) in Kazakhstan, in 2008. Avian influenza monitoring in wild birds especially in migratory hotspots such as central Asia is an important approach to gain information about the circulation of known and novel influenza viruses. Genetically, the novel HA coding sequence exhibits only 68.2% nucleotide and 68.5% amino acid identity with its nearest relation in the H9 (N2) subtype. The new HA sequence should be considered in current genomic diagnostic AI assays to facilitate its detection and eventual isolation enabling further study and antigenic classification.https://www.tandfonline.com/doi/10.1080/22221751.2023.2225645Influenza A virusesinfluenza subtypesone-healthwild birdsKazakhstan |
| spellingShingle | Sasan Fereidouni Elke Starick Kobey Karamendin Cecilia Di Genova Simon D. Scott Yelizaveta Khan Timm Harder Aidyn Kydyrmanov Genetic characterization of a new candidate hemagglutinin subtype of influenza A viruses Emerging Microbes and Infections Influenza A viruses influenza subtypes one-health wild birds Kazakhstan |
| title | Genetic characterization of a new candidate hemagglutinin subtype of influenza A viruses |
| title_full | Genetic characterization of a new candidate hemagglutinin subtype of influenza A viruses |
| title_fullStr | Genetic characterization of a new candidate hemagglutinin subtype of influenza A viruses |
| title_full_unstemmed | Genetic characterization of a new candidate hemagglutinin subtype of influenza A viruses |
| title_short | Genetic characterization of a new candidate hemagglutinin subtype of influenza A viruses |
| title_sort | genetic characterization of a new candidate hemagglutinin subtype of influenza a viruses |
| topic | Influenza A viruses influenza subtypes one-health wild birds Kazakhstan |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2023.2225645 |
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