Histopathological evaluation of effects of high fructose diet on bone healing in tibial defects: An Experimental study
The purpose of this study was to examine the impact of a high- fructose diet on bone regeneration in defects created in rat tibias. The experimental setup was performed with 24 female Sprague-Dawley rats in the same estrus period; the rats were divided into two groups as control and experimental gr...
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Universidad del Zulia
2025-05-01
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| Series: | Revista Científica |
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| Online Access: | https://produccioncientificaluz.org/index.php/cientifica/article/view/43858 |
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| author | Can Ayhan Kaya Aslı Sagsoz Murat Tanrisever Turker Gelic Ibrahim Hanifi Ozercan Serkan Dundar |
| author_facet | Can Ayhan Kaya Aslı Sagsoz Murat Tanrisever Turker Gelic Ibrahim Hanifi Ozercan Serkan Dundar |
| author_sort | Can Ayhan Kaya |
| collection | DOAJ |
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The purpose of this study was to examine the impact of a high- fructose diet on bone regeneration in defects created in rat tibias. The experimental setup was performed with 24 female Sprague-Dawley rats in the same estrus period; the rats were divided into two groups as control and experimental groups. In the control defect group (n=12), a cylindrical defect of 4 mm in diameter and 4 mm in depth was surgically created in the corticocancellous bone of the metaphyseal part of the right tibia of each rat. No other application was made in this group during the experimental setup. For each rat in the high- fructose-fed defect group (n=12), cylindrical defects of 4 mm in diameter and 4 mm in depth were surgically created in the corticocancellous bone of the metaphyseal part of the right tibia. Fructose supplements of the groups were added to the drinking water at a rate of 20% (w/v). All rats were sacrificed at the end of the 12th week of the surgical application. The histological samples were evaluated under a light microscope. There was no significant differences in the bone regeneration between control animals and high fructose diet consumption group.52.2 ± 9 % for Controls, versus 49.8 ± 7.67 % for HFD (P>0,05). Further research is needed to determine the mechanisms responsible for these changes in bone structure and how these changes affect bone quality and strength with age.
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| format | Article |
| id | doaj-art-9a873b8f57544e81b93d9c5fed2a77de |
| institution | DOAJ |
| issn | 0798-2259 2521-9715 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Universidad del Zulia |
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| series | Revista Científica |
| spelling | doaj-art-9a873b8f57544e81b93d9c5fed2a77de2025-08-20T03:13:10ZengUniversidad del ZuliaRevista Científica0798-22592521-97152025-05-0135210.52973/rcfcv-e35624Histopathological evaluation of effects of high fructose diet on bone healing in tibial defects: An Experimental studyCan Ayhan Kaya0Aslı Sagsoz1Murat Tanrisever2Turker Gelic3Ibrahim Hanifi Ozercan4Serkan Dundar 5Diyarbakir Agriculture Vocational School, Department of Plant and Animal Production, Dicle University, Diyarbakir, Turkiye.Bursa Duacinari Oral and Dental Health Center, Ministry of Health, Bursa, Turkiye.Department of Surgery, Faculty of Veterinary Medicine, Firat University, Elazig, Türkiye.Department of Surgery, Faculty of Veterinary Medicine, Firat University, Elazig, Türkiye.Department of Pathology, Faculty of Medicine, Firat University, Elazig, Türkiye.Department of Peridontology, Faculty of Dentistry, Firat University, Elazig, Türkiye. The purpose of this study was to examine the impact of a high- fructose diet on bone regeneration in defects created in rat tibias. The experimental setup was performed with 24 female Sprague-Dawley rats in the same estrus period; the rats were divided into two groups as control and experimental groups. In the control defect group (n=12), a cylindrical defect of 4 mm in diameter and 4 mm in depth was surgically created in the corticocancellous bone of the metaphyseal part of the right tibia of each rat. No other application was made in this group during the experimental setup. For each rat in the high- fructose-fed defect group (n=12), cylindrical defects of 4 mm in diameter and 4 mm in depth were surgically created in the corticocancellous bone of the metaphyseal part of the right tibia. Fructose supplements of the groups were added to the drinking water at a rate of 20% (w/v). All rats were sacrificed at the end of the 12th week of the surgical application. The histological samples were evaluated under a light microscope. There was no significant differences in the bone regeneration between control animals and high fructose diet consumption group.52.2 ± 9 % for Controls, versus 49.8 ± 7.67 % for HFD (P>0,05). Further research is needed to determine the mechanisms responsible for these changes in bone structure and how these changes affect bone quality and strength with age. https://produccioncientificaluz.org/index.php/cientifica/article/view/43858Fructosehigh fructose dietbone healingbone metabolismbone formation |
| spellingShingle | Can Ayhan Kaya Aslı Sagsoz Murat Tanrisever Turker Gelic Ibrahim Hanifi Ozercan Serkan Dundar Histopathological evaluation of effects of high fructose diet on bone healing in tibial defects: An Experimental study Revista Científica Fructose high fructose diet bone healing bone metabolism bone formation |
| title | Histopathological evaluation of effects of high fructose diet on bone healing in tibial defects: An Experimental study |
| title_full | Histopathological evaluation of effects of high fructose diet on bone healing in tibial defects: An Experimental study |
| title_fullStr | Histopathological evaluation of effects of high fructose diet on bone healing in tibial defects: An Experimental study |
| title_full_unstemmed | Histopathological evaluation of effects of high fructose diet on bone healing in tibial defects: An Experimental study |
| title_short | Histopathological evaluation of effects of high fructose diet on bone healing in tibial defects: An Experimental study |
| title_sort | histopathological evaluation of effects of high fructose diet on bone healing in tibial defects an experimental study |
| topic | Fructose high fructose diet bone healing bone metabolism bone formation |
| url | https://produccioncientificaluz.org/index.php/cientifica/article/view/43858 |
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