The Impact of Hydrogen Sulfide Regulatory Gene Alterations on Head and neck squamous cell carcinoma prognosis and tumor microenvironment

The Impact of Hydrogen Sulfide Regulatory Gene Alterations on Head and neck squamous cell carcinoma prognosis and tumor microenvironment

Abstract Background Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer globally, with high morbidity and mortality due to late-stage diagnoses, treatment resistance, and recurrence. Hydrogen sulfide (H2S) metabolism, primarily regulated by cystathionine gamma-lyase (CTH) a...

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Bibliographic Details
Main Authors: Mohamed Rizwan Ghouse, Santhakumar Egambaram, Arunkumar Ramachandran, Rajesh Parsanathan
Format: Article
Language:English
Published: SpringerOpen 2025-04-01
Series:Egyptian Journal of Medical Human Genetics
Subjects:
H2S regulatory genes
HNSCC
Gene expression
Promoter methylation
Survival analysis
Tumour microenvironment
Online Access:https://doi.org/10.1186/s43042-025-00715-6
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