Association between ABCB1 Gene Polymorphisms and Labor Analgesia in Primiparas
Background: The present study aimed to explore the association of ATP-binding cassette B1 (ABCB1)/multiple drug resistance 1 (MDR1) gene polymorphisms (rs1128503 and rs1045642) with labor analgesia in primiparas....
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IMR Press
2024-09-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
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| Online Access: | https://www.imrpress.com/journal/CEOG/51/9/10.31083/j.ceog5109200 |
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| author | Wei Li Tianke Xiao Xuehui Wu Xinyu Wu Rui Xiang Haifeng Liu Jingyi Wang |
| author_facet | Wei Li Tianke Xiao Xuehui Wu Xinyu Wu Rui Xiang Haifeng Liu Jingyi Wang |
| author_sort | Wei Li |
| collection | DOAJ |
| description | Background: The present study aimed to explore the association of ATP-binding cassette B1 (ABCB1)/multiple drug resistance 1 (MDR1) gene polymorphisms (rs1128503 and rs1045642) with labor analgesia in primiparas. Methods: The cohort comprised 239 primiparas who received epidural analgesia (0.5 μg/L sufentanil + 0.1% ropivacaine). Visual analog scale (VAS) scores were recorded at 0, 1, and 2 h, respectively, after epidural analgesia. The outcomes (VAS score and adverse reactions) of labor analgesia among patients carrying different genotypes of ABCB1 gene polymorphisms were compared using a one-way analysis of variance (ANOVA) or chi-square test. ABCB1 polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The correlation between ABCB1 gene polymorphisms and labor analgesia outcomes (including VAS score and adverse reactions) was evaluated using logistic regression analysis. Results: Genotype distributions of rs1128503 and rs1045642 polymorphisms were detected using Hardy-Weinberg equilibrium (HWE) test. Age, body mass index, and gestational age did not differ significantly between genotypes of rs1128503 and rs1045642 polymorphisms. A higher 2 h-VAS score was observed in the rs1045642 TT genotype than in the rs1045642 CC and CT genotypes, while abnormal fetal heart rate (FHR) monitoring and 1 min Apgar scores were frequently discovered in patients with the rs1128503 TT genotype (p < 0.05). Logistic regression analysis suggested that 2 h-VAS score (p = 0.025, odds ratio (OR) = 0.497, 95% confidence interval (95% CI) = 0.270–0.915), nausea (p = 0.042, OR = 0.188, 95% CI = 0.038–0.940) and Apgar score at 1 min (p = 0.026, OR = 1.774, 95% CI = 1.069–2.942) were distinctly correlated with the rs1128503 TC + CC genotypes. VAS 2 h score (p = 0.000, OR = 3.673, 95% CI = 1.900–7.101) was positively related to the rs1045642 CT + TT genotypes. Conclusions: ABCB1 gene rs1128503 and rs1045642 polymorphisms were significantly correlated with the analgesic effect and adverse reactions of labor analgesia in primiparas. |
| format | Article |
| id | doaj-art-9a84b7aca87d4736879c9a0232f7eb09 |
| institution | Kabale University |
| issn | 0390-6663 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | IMR Press |
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| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj-art-9a84b7aca87d4736879c9a0232f7eb092025-08-20T03:36:53ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632024-09-0151920010.31083/j.ceog5109200S0390-6663(24)02413-8Association between ABCB1 Gene Polymorphisms and Labor Analgesia in PrimiparasWei Li0Tianke Xiao1Xuehui Wu2Xinyu Wu3Rui Xiang4Haifeng Liu5Jingyi Wang6Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chengdu Medical College (China National Nuclear Corporation 416 Hospital), 610052 Chengdu, Sichuan, ChinaDepartment of Anesthesiology, The Second Affiliated Hospital of Chengdu Medical College (China National Nuclear Corporation 416 Hospital), 610052 Chengdu, Sichuan, ChinaDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Chengdu Medical College (China National Nuclear Corporation 416 Hospital), 610052 Chengdu, Sichuan, ChinaDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Chengdu Medical College (China National Nuclear Corporation 416 Hospital), 610052 Chengdu, Sichuan, ChinaDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Chengdu Medical College (China National Nuclear Corporation 416 Hospital), 610052 Chengdu, Sichuan, ChinaDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Chengdu Medical College (China National Nuclear Corporation 416 Hospital), 610052 Chengdu, Sichuan, ChinaDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Chengdu Medical College (China National Nuclear Corporation 416 Hospital), 610052 Chengdu, Sichuan, ChinaBackground: The present study aimed to explore the association of ATP-binding cassette B1 (ABCB1)/multiple drug resistance 1 (MDR1) gene polymorphisms (rs1128503 and rs1045642) with labor analgesia in primiparas. Methods: The cohort comprised 239 primiparas who received epidural analgesia (0.5 μg/L sufentanil + 0.1% ropivacaine). Visual analog scale (VAS) scores were recorded at 0, 1, and 2 h, respectively, after epidural analgesia. The outcomes (VAS score and adverse reactions) of labor analgesia among patients carrying different genotypes of ABCB1 gene polymorphisms were compared using a one-way analysis of variance (ANOVA) or chi-square test. ABCB1 polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The correlation between ABCB1 gene polymorphisms and labor analgesia outcomes (including VAS score and adverse reactions) was evaluated using logistic regression analysis. Results: Genotype distributions of rs1128503 and rs1045642 polymorphisms were detected using Hardy-Weinberg equilibrium (HWE) test. Age, body mass index, and gestational age did not differ significantly between genotypes of rs1128503 and rs1045642 polymorphisms. A higher 2 h-VAS score was observed in the rs1045642 TT genotype than in the rs1045642 CC and CT genotypes, while abnormal fetal heart rate (FHR) monitoring and 1 min Apgar scores were frequently discovered in patients with the rs1128503 TT genotype (p < 0.05). Logistic regression analysis suggested that 2 h-VAS score (p = 0.025, odds ratio (OR) = 0.497, 95% confidence interval (95% CI) = 0.270–0.915), nausea (p = 0.042, OR = 0.188, 95% CI = 0.038–0.940) and Apgar score at 1 min (p = 0.026, OR = 1.774, 95% CI = 1.069–2.942) were distinctly correlated with the rs1128503 TC + CC genotypes. VAS 2 h score (p = 0.000, OR = 3.673, 95% CI = 1.900–7.101) was positively related to the rs1045642 CT + TT genotypes. Conclusions: ABCB1 gene rs1128503 and rs1045642 polymorphisms were significantly correlated with the analgesic effect and adverse reactions of labor analgesia in primiparas.https://www.imrpress.com/journal/CEOG/51/9/10.31083/j.ceog5109200labor analgesiaprimiparasabcb1polymorphisms |
| spellingShingle | Wei Li Tianke Xiao Xuehui Wu Xinyu Wu Rui Xiang Haifeng Liu Jingyi Wang Association between ABCB1 Gene Polymorphisms and Labor Analgesia in Primiparas Clinical and Experimental Obstetrics & Gynecology labor analgesia primiparas abcb1 polymorphisms |
| title | Association between ABCB1 Gene Polymorphisms and Labor Analgesia in Primiparas |
| title_full | Association between ABCB1 Gene Polymorphisms and Labor Analgesia in Primiparas |
| title_fullStr | Association between ABCB1 Gene Polymorphisms and Labor Analgesia in Primiparas |
| title_full_unstemmed | Association between ABCB1 Gene Polymorphisms and Labor Analgesia in Primiparas |
| title_short | Association between ABCB1 Gene Polymorphisms and Labor Analgesia in Primiparas |
| title_sort | association between abcb1 gene polymorphisms and labor analgesia in primiparas |
| topic | labor analgesia primiparas abcb1 polymorphisms |
| url | https://www.imrpress.com/journal/CEOG/51/9/10.31083/j.ceog5109200 |
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