Pneumococcal serotype prevalence and antibiotic resistance in children in South and Southeast Asia, 2012–2024
This narrative review describes pneumococcal serotype prevalence for invasive disease and carriage and antibiotic resistance among specimens collected from children in countries across South and Southeast Asia from 2012 to 2024. Literature search retrieved 326 articles; 96 were included. The prevale...
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| Format: | Article |
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Taylor & Francis Group
2024-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2024.2417554 |
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| author | Tzou-Yien Lin Cheng-Hsun Chiu Patrick CY Woo Abdul Razak Muttalif Raja Dhar Leong Choon Kit Graciela Morales Egemen Ozbilgili |
| author_facet | Tzou-Yien Lin Cheng-Hsun Chiu Patrick CY Woo Abdul Razak Muttalif Raja Dhar Leong Choon Kit Graciela Morales Egemen Ozbilgili |
| author_sort | Tzou-Yien Lin |
| collection | DOAJ |
| description | This narrative review describes pneumococcal serotype prevalence for invasive disease and carriage and antibiotic resistance among specimens collected from children in countries across South and Southeast Asia from 2012 to 2024. Literature search retrieved 326 articles; 96 were included. The prevalence of pneumococcal serotypes varied geographically and over time after introduction of pneumococcal conjugate vaccine. Serotypes common in both pneumococcal carriage and disease were 6A, 6B, 14, 15B/15C, 19F, and 23F; serotypes 1, 3, 5, 19A, 15A, 10A, and 35B were also common in disease. Most of these serotypes are included in the 13-valent and 10-valent PCV. Carriage and disease isolates remained generally highly susceptible to vancomycin (mostly 100%) and levofloxacin (mostly >97%). These findings indicate that vaccine-preventable serotypes contribute significantly to pneumococcal disease burden in children in South and Southeast Asia. Consistency of national immunization programs with World Health Organization recommendations may reduce rates of pneumococcal disease in this region. |
| format | Article |
| id | doaj-art-9a80d033012c4f2ca1f5bbdeaf8ec48b |
| institution | OA Journals |
| issn | 2164-5515 2164-554X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj-art-9a80d033012c4f2ca1f5bbdeaf8ec48b2025-08-20T02:16:44ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2024-12-0120110.1080/21645515.2024.2417554Pneumococcal serotype prevalence and antibiotic resistance in children in South and Southeast Asia, 2012–2024Tzou-Yien Lin0Cheng-Hsun Chiu1Patrick CY Woo2Abdul Razak Muttalif3Raja Dhar4Leong Choon Kit5Graciela Morales6Egemen Ozbilgili7Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, TaiwanDepartment of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, TaiwanDepartment of Microbiology, University of Hong Kong, Hong Kong, ChinaDepartment of Medicine, Faculty of Medicine, MAHSA University, Jenjarom, Selangor, MalaysiaDepartment of Pulmonology, Calcutta Medical Research Institute, Kolkata, IndiaTampines Family Medicine Clinic, Mission Medical Clinic, Hougang, SingaporeEmerging Markets Medical Affairs, Vaccines, Pfizer Inc, San Jose, Costa RicaEmerging Markets Medical Affairs, Vaccines, Pfizer Pte Ltd., Singapore, SingaporeThis narrative review describes pneumococcal serotype prevalence for invasive disease and carriage and antibiotic resistance among specimens collected from children in countries across South and Southeast Asia from 2012 to 2024. Literature search retrieved 326 articles; 96 were included. The prevalence of pneumococcal serotypes varied geographically and over time after introduction of pneumococcal conjugate vaccine. Serotypes common in both pneumococcal carriage and disease were 6A, 6B, 14, 15B/15C, 19F, and 23F; serotypes 1, 3, 5, 19A, 15A, 10A, and 35B were also common in disease. Most of these serotypes are included in the 13-valent and 10-valent PCV. Carriage and disease isolates remained generally highly susceptible to vancomycin (mostly 100%) and levofloxacin (mostly >97%). These findings indicate that vaccine-preventable serotypes contribute significantly to pneumococcal disease burden in children in South and Southeast Asia. Consistency of national immunization programs with World Health Organization recommendations may reduce rates of pneumococcal disease in this region.https://www.tandfonline.com/doi/10.1080/21645515.2024.2417554Childrenpneumococcal diseaseserotypepneumococcal conjugate vaccineinvasive pneumococcal diseaseantibiotic resistance |
| spellingShingle | Tzou-Yien Lin Cheng-Hsun Chiu Patrick CY Woo Abdul Razak Muttalif Raja Dhar Leong Choon Kit Graciela Morales Egemen Ozbilgili Pneumococcal serotype prevalence and antibiotic resistance in children in South and Southeast Asia, 2012–2024 Human Vaccines & Immunotherapeutics Children pneumococcal disease serotype pneumococcal conjugate vaccine invasive pneumococcal disease antibiotic resistance |
| title | Pneumococcal serotype prevalence and antibiotic resistance in children in South and Southeast Asia, 2012–2024 |
| title_full | Pneumococcal serotype prevalence and antibiotic resistance in children in South and Southeast Asia, 2012–2024 |
| title_fullStr | Pneumococcal serotype prevalence and antibiotic resistance in children in South and Southeast Asia, 2012–2024 |
| title_full_unstemmed | Pneumococcal serotype prevalence and antibiotic resistance in children in South and Southeast Asia, 2012–2024 |
| title_short | Pneumococcal serotype prevalence and antibiotic resistance in children in South and Southeast Asia, 2012–2024 |
| title_sort | pneumococcal serotype prevalence and antibiotic resistance in children in south and southeast asia 2012 2024 |
| topic | Children pneumococcal disease serotype pneumococcal conjugate vaccine invasive pneumococcal disease antibiotic resistance |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2024.2417554 |
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