Short‐ and Long‐Term Efficacy of Hyperbaric Oxygen Therapy in Irradiated Breast Cancer Patients With Long‐Standing Lymphedema: A Prospective Case Series
ABSTRACT Background Several studies have explored the advantage of treatment with hyperbaric oxygen (HBO) for upper extremity lymphedema in irradiated breast cancer patients and reported controversial results. This prospective case series aimed to document the short‐ and long‐term efficacy of this t...
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2025-01-01
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| Series: | Cancer Reports |
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| Online Access: | https://doi.org/10.1002/cnr2.70109 |
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| author | Imjai Chitapanarux Siriarrayapa Chachvarat Patumrat Sripan Thienchai Pattarasakulchai Nuttaya Pattamapaspong Thanat Kanthawang Montana Buntragulpoontawee |
| author_facet | Imjai Chitapanarux Siriarrayapa Chachvarat Patumrat Sripan Thienchai Pattarasakulchai Nuttaya Pattamapaspong Thanat Kanthawang Montana Buntragulpoontawee |
| author_sort | Imjai Chitapanarux |
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| description | ABSTRACT Background Several studies have explored the advantage of treatment with hyperbaric oxygen (HBO) for upper extremity lymphedema in irradiated breast cancer patients and reported controversial results. This prospective case series aimed to document the short‐ and long‐term efficacy of this therapy, focusing on the arm volume and functional assessment in breast cancer patients with a history of long‐standing lymphedema for more than 2 years. Case Six breast cancer patients with long‐standing lymphedema were enrolled. All of them received breast surgery and dissection of axillary lymph nodes, chemotherapy, and postoperative radiotherapy. The average duration from the onset of lymphedema to HBO treatment was 9 ± 5.92 years (range 2–17). All patients were treated for 90 min in the HBO chamber with 100% oxygen at a higher pressure of two times the atmospheric pressure, five times a week for 30 sessions. We measured the circumference of both arms and calculated the arm volume before treatment (baseline), after 30 sessions of treatment, and after treatment at 3, 6, and 24 months. Functional assessment focused on the ability of the arm, shoulder, and hand using the Thai Quick‐DASH questionnaires, which were assessed by the patients at the same periods. The change of arm volume and Thai Quick‐DASH score at each time point were compared to the starting point data before HBO. Conclusion The change of arm volume and mean Quick‐DASH score had decreased at 3, 6, and 24 months after treatment compared to the starting point before HBO, However, these changes were not statistically significant. |
| format | Article |
| id | doaj-art-9a7efb9ffe064206b41480f6fef32e29 |
| institution | Kabale University |
| issn | 2573-8348 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Reports |
| spelling | doaj-art-9a7efb9ffe064206b41480f6fef32e292025-01-30T15:46:35ZengWileyCancer Reports2573-83482025-01-0181n/an/a10.1002/cnr2.70109Short‐ and Long‐Term Efficacy of Hyperbaric Oxygen Therapy in Irradiated Breast Cancer Patients With Long‐Standing Lymphedema: A Prospective Case SeriesImjai Chitapanarux0Siriarrayapa Chachvarat1Patumrat Sripan2Thienchai Pattarasakulchai3Nuttaya Pattamapaspong4Thanat Kanthawang5Montana Buntragulpoontawee6Division of Radiation Oncology, Department of Radiology Chiang Mai University Chiang Mai ThailandNakhon Si Thammarat Cancer Hospital, Nakhon Si Thammarat Nakhon Si Thammarat ThailandResearch Institute for Health Sciences Chiang Mai University Chiang Mai ThailandHyperbaric Oxygen Therapy Center, Chiang Mai University Chiang Mai ThailandDivision of Diagnostic Radiology, Department of Radiology Chiang Mai University Chiang Mai ThailandDivision of Diagnostic Radiology, Department of Radiology Chiang Mai University Chiang Mai ThailandNeuro‐Mobility Unit, Department of Rehabilitation Medicine Chiang Mai University Chiang Mai ThailandABSTRACT Background Several studies have explored the advantage of treatment with hyperbaric oxygen (HBO) for upper extremity lymphedema in irradiated breast cancer patients and reported controversial results. This prospective case series aimed to document the short‐ and long‐term efficacy of this therapy, focusing on the arm volume and functional assessment in breast cancer patients with a history of long‐standing lymphedema for more than 2 years. Case Six breast cancer patients with long‐standing lymphedema were enrolled. All of them received breast surgery and dissection of axillary lymph nodes, chemotherapy, and postoperative radiotherapy. The average duration from the onset of lymphedema to HBO treatment was 9 ± 5.92 years (range 2–17). All patients were treated for 90 min in the HBO chamber with 100% oxygen at a higher pressure of two times the atmospheric pressure, five times a week for 30 sessions. We measured the circumference of both arms and calculated the arm volume before treatment (baseline), after 30 sessions of treatment, and after treatment at 3, 6, and 24 months. Functional assessment focused on the ability of the arm, shoulder, and hand using the Thai Quick‐DASH questionnaires, which were assessed by the patients at the same periods. The change of arm volume and Thai Quick‐DASH score at each time point were compared to the starting point data before HBO. Conclusion The change of arm volume and mean Quick‐DASH score had decreased at 3, 6, and 24 months after treatment compared to the starting point before HBO, However, these changes were not statistically significant.https://doi.org/10.1002/cnr2.70109efficacyhyperbaric oxygen treatmentlong standinglymphedema |
| spellingShingle | Imjai Chitapanarux Siriarrayapa Chachvarat Patumrat Sripan Thienchai Pattarasakulchai Nuttaya Pattamapaspong Thanat Kanthawang Montana Buntragulpoontawee Short‐ and Long‐Term Efficacy of Hyperbaric Oxygen Therapy in Irradiated Breast Cancer Patients With Long‐Standing Lymphedema: A Prospective Case Series Cancer Reports efficacy hyperbaric oxygen treatment long standing lymphedema |
| title | Short‐ and Long‐Term Efficacy of Hyperbaric Oxygen Therapy in Irradiated Breast Cancer Patients With Long‐Standing Lymphedema: A Prospective Case Series |
| title_full | Short‐ and Long‐Term Efficacy of Hyperbaric Oxygen Therapy in Irradiated Breast Cancer Patients With Long‐Standing Lymphedema: A Prospective Case Series |
| title_fullStr | Short‐ and Long‐Term Efficacy of Hyperbaric Oxygen Therapy in Irradiated Breast Cancer Patients With Long‐Standing Lymphedema: A Prospective Case Series |
| title_full_unstemmed | Short‐ and Long‐Term Efficacy of Hyperbaric Oxygen Therapy in Irradiated Breast Cancer Patients With Long‐Standing Lymphedema: A Prospective Case Series |
| title_short | Short‐ and Long‐Term Efficacy of Hyperbaric Oxygen Therapy in Irradiated Breast Cancer Patients With Long‐Standing Lymphedema: A Prospective Case Series |
| title_sort | short and long term efficacy of hyperbaric oxygen therapy in irradiated breast cancer patients with long standing lymphedema a prospective case series |
| topic | efficacy hyperbaric oxygen treatment long standing lymphedema |
| url | https://doi.org/10.1002/cnr2.70109 |
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