Preliminary investigation of Ru(II) complexes bearing nile red chromophores for photodynamic therapy
Two previously investigated Ru(II) triplet photosensitisers (PS) ([Ru-2ENR][(PF6)2] and [Ru-3ENR][(PF6)2]) comprising a bipyridyl frame and acetylene appended Nile red chromophore, were converted to their chloride salts for cytotoxicity and phototoxicity measurements. SKBR3-cell lines were used to e...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Chemical Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fchbi.2025.1620562/full |
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| Summary: | Two previously investigated Ru(II) triplet photosensitisers (PS) ([Ru-2ENR][(PF6)2] and [Ru-3ENR][(PF6)2]) comprising a bipyridyl frame and acetylene appended Nile red chromophore, were converted to their chloride salts for cytotoxicity and phototoxicity measurements. SKBR3-cell lines were used to evaluate the photodynamic activity of the compounds. Irradiation (λex 630 nm; 15 min; 33 J cm−2) at a non-toxic concentration of 10 nM, [Ru-2ENR][(PF6)2] and [Ru-3ENR][(PF6)2] induced a reduction in metabolic activity by 60% and 30% respectively. |
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| ISSN: | 2813-530X |