Enhancing gene transfer to renal tubules and podocytes by context-dependent selection of AAV capsids

Enhancing gene transfer to renal tubules and podocytes by context-dependent selection of AAV capsids

Abstract AAV vectors show promise for gene therapy; however, kidney gene transfer remains challenging. Here we conduct a barcode-seq-based comparison of 47 AAV capsids administered through different routes in mice, followed by individual validation. We find that local delivery of AAV-KP1, but not AA...

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Main Authors: Taisuke Furusho, Ranjan Das, Hideyuki Hakui, Anusha Sairavi, Kei Adachi, Mia S. Galbraith-Liss, Pratheppa Rajagopal, Masahiro Horikawa, Shuhua Luo, Lena Li, Kentaro Yamada, Nicole Andeen, Gregory A. Dissen, Hiroyuki Nakai
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54475-9
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