Exploring the effect of glabellar Botulinum toxin injections on symptoms of anxiety and depression: A pilot study from a cosmetic patient population
Botulinum toxin (BT) injections to the glabellar region are emerging as a promising investigational treatment for multiple mental health conditions. By paralyzing the muscles involved in frowning, this intervention is postulated by the facial feedback hypothesis to reduce the intensity of negative a...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-12-01
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| Series: | Journal of Dermatologic Science and Cosmetic Technology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950306X24000566 |
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| author | Michael K. Wolfe Arisa Ortiz Rona Z. Silkiss |
| author_facet | Michael K. Wolfe Arisa Ortiz Rona Z. Silkiss |
| author_sort | Michael K. Wolfe |
| collection | DOAJ |
| description | Botulinum toxin (BT) injections to the glabellar region are emerging as a promising investigational treatment for multiple mental health conditions. By paralyzing the muscles involved in frowning, this intervention is postulated by the facial feedback hypothesis to reduce the intensity of negative affective states and has a growing body of evidence for treating major depression. However, applications to other psychiatric conditions have been relatively unexplored. This is the first study to our knowledge to examine the effect of glabellar BT on generalized anxiety. By tracking GAD-7 scores of a cosmetic population before and after receipt of glabellar BT, we observed a statistically significant decrease of anxious symptoms among patients who entered the study with a baseline level of clinical anxiety. Though more research is needed, our results suggest glabellar BT has the potential to improve symptoms of mild to moderate generalized anxiety. |
| format | Article |
| id | doaj-art-9a79ad7bfc314faf89d84d6188cab3e4 |
| institution | DOAJ |
| issn | 2950-306X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Journal of Dermatologic Science and Cosmetic Technology |
| spelling | doaj-art-9a79ad7bfc314faf89d84d6188cab3e42025-08-20T03:09:34ZengKeAi Communications Co., Ltd.Journal of Dermatologic Science and Cosmetic Technology2950-306X2024-12-011410005810.1016/j.jdsct.2024.100058Exploring the effect of glabellar Botulinum toxin injections on symptoms of anxiety and depression: A pilot study from a cosmetic patient populationMichael K. Wolfe0Arisa Ortiz1Rona Z. Silkiss2Department of Psychiatry, University of California, 350 Dickinson St, Ste 3- 325, San Diego, CA 92103, USA; Corresponding author.Department of Dermatology, University of California, 8899 University Center Ln, Ste 350, San Diego, CA 92122, USSilkiss Eye Surgery, 400 29th St, Ste 315, Oakland, CA 94609, USABotulinum toxin (BT) injections to the glabellar region are emerging as a promising investigational treatment for multiple mental health conditions. By paralyzing the muscles involved in frowning, this intervention is postulated by the facial feedback hypothesis to reduce the intensity of negative affective states and has a growing body of evidence for treating major depression. However, applications to other psychiatric conditions have been relatively unexplored. This is the first study to our knowledge to examine the effect of glabellar BT on generalized anxiety. By tracking GAD-7 scores of a cosmetic population before and after receipt of glabellar BT, we observed a statistically significant decrease of anxious symptoms among patients who entered the study with a baseline level of clinical anxiety. Though more research is needed, our results suggest glabellar BT has the potential to improve symptoms of mild to moderate generalized anxiety.http://www.sciencedirect.com/science/article/pii/S2950306X24000566Botulinum toxinGeneralized anxiety disorderGlabellar injectionsFacial feedback hypothesisNeuromodulatory treatments |
| spellingShingle | Michael K. Wolfe Arisa Ortiz Rona Z. Silkiss Exploring the effect of glabellar Botulinum toxin injections on symptoms of anxiety and depression: A pilot study from a cosmetic patient population Journal of Dermatologic Science and Cosmetic Technology Botulinum toxin Generalized anxiety disorder Glabellar injections Facial feedback hypothesis Neuromodulatory treatments |
| title | Exploring the effect of glabellar Botulinum toxin injections on symptoms of anxiety and depression: A pilot study from a cosmetic patient population |
| title_full | Exploring the effect of glabellar Botulinum toxin injections on symptoms of anxiety and depression: A pilot study from a cosmetic patient population |
| title_fullStr | Exploring the effect of glabellar Botulinum toxin injections on symptoms of anxiety and depression: A pilot study from a cosmetic patient population |
| title_full_unstemmed | Exploring the effect of glabellar Botulinum toxin injections on symptoms of anxiety and depression: A pilot study from a cosmetic patient population |
| title_short | Exploring the effect of glabellar Botulinum toxin injections on symptoms of anxiety and depression: A pilot study from a cosmetic patient population |
| title_sort | exploring the effect of glabellar botulinum toxin injections on symptoms of anxiety and depression a pilot study from a cosmetic patient population |
| topic | Botulinum toxin Generalized anxiety disorder Glabellar injections Facial feedback hypothesis Neuromodulatory treatments |
| url | http://www.sciencedirect.com/science/article/pii/S2950306X24000566 |
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