Polygenic risk scores for pan-cancer risk prediction in the Chinese population: A population-based cohort study based on the China Kadoorie Biobank.

Polygenic risk scores for pan-cancer risk prediction in the Chinese population: A population-based cohort study based on the China Kadoorie Biobank.

<h4>Background</h4>Polygenic risk scores (PRSs) have been extensively developed for cancer risk prediction in European populations, but their effectiveness in the Chinese population remains uncertain.<h4>Methods and findings</h4>We constructed 80 PRSs for the 13 most common c...

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Main Authors: Meng Zhu, Xia Zhu, Yuting Han, Zhimin Ma, Chen Ji, Tianpei Wang, Caiwang Yan, Ci Song, Canqing Yu, Dianjianyi Sun, Yue Jiang, Jiaping Chen, Ling Yang, Yiping Chen, Huaidong Du, Robin Walters, Iona Y Millwood, Juncheng Dai, Hongxia Ma, Zhengdong Zhang, Zhengming Chen, Zhibin Hu, Jun Lv, Guangfu Jin, Liming Li, Hongbing Shen, China Kadoorie Biobank Collaborative Group
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-02-01
Series:PLoS Medicine
Online Access:https://doi.org/10.1371/journal.pmed.1004534
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