Effect of BMI on serum magnesium level in patient getting Pritchard regimen
Background: Maternal death due to severe preeclampsia and eclampsia has significantly reduced in developed countries due to revolutionary management by magnesium sulphate, but it’s still very high in developing countries including India. Many factors including BMI may have significant role in seru...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Barpeta Obstetrics and Gynaecological Society
2024-05-01
|
| Series: | New Indian Journal of OBGYN |
| Subjects: | |
| Online Access: | https://journal.barpetaogs.co.in/pdf/10257.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Background: Maternal death due to severe preeclampsia and eclampsia has significantly reduced in developed
countries due to revolutionary management by magnesium sulphate, but it’s still very high in developing countries
including India. Many factors including BMI may have significant role in serum magnesium level in patients getting
prophylactic and therapeutic treatment with Pritchard regimen. Objectives: To assess the effect of body mass index
on serum magnesium level in patients getting magnesium sulphate therapy for seizure prophylaxis. Methods: The
study was conducted over one year period from June 2021 to July 2022 in Assam Medical College, Dibrugarh among
160 severe preeclampsia and eclampsia patients who were getting Pritchard regimen. Serum magnesium was
measured after loading dose, 3rd dose and 24 hours after last dose. Patients were divided in different groups as per
WHO BMI categories. Results: After loading dose mean serum magnesium levels of patients with BMI < 18.5, 18.5-
24.99, 25-29.99 and ≥30 were 3.91±1.09 mg/dl, 3.42± 0.97 mg/dl, 3.20±0.81 mg/dl and 2.77±0.67 mg/dl respectively.
Although p- value (0.0616) was not significant but decrease in serum magnesium level was noted with increased BMI.
After 3rd dose mean serum magnesium of patients with BMI < 18.5, 18.5-24.99, 25-29.99 and ≥30 were 6.76 ± 0.95
mg/dl, 6.34±1.15 mg/dl, 5.83±1.02 mg/dl and 5.58 ± 1.00 mg/dl respectively. Difference was statistically significant
(p=0.0001). Convulsion rate was higher in obese patient (13.04%) compared to non-obese (2.91%). Conclusion: BMI
has a significant role on serum magnesium level in pregnant women getting magnesium sulphate therapy for seizure
prophylaxis. |
|---|---|
| ISSN: | 2454-2334 2454-2342 |