Lenvatinib in combination with pembrolizumab as first-line therapy for advanced endometrial cancer: clinical case
The combination of lenvatinib and pembrolizumab has emerged as the first non-chemo treatment for advanced endometrial cancer, particularly in cases refractory to standard therapies. This case describes the efficacy and safety of the combination of lenvatinib and pembrolizumab in the treatment of a 6...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2025-05-01
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| Series: | Опухоли женской репродуктивной системы |
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| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/1356 |
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| author | E. A. Khachaturyan T. G. Antonova O. A. Stativko I. A. Pokataev |
| author_facet | E. A. Khachaturyan T. G. Antonova O. A. Stativko I. A. Pokataev |
| author_sort | E. A. Khachaturyan |
| collection | DOAJ |
| description | The combination of lenvatinib and pembrolizumab has emerged as the first non-chemo treatment for advanced endometrial cancer, particularly in cases refractory to standard therapies. This case describes the efficacy and safety of the combination of lenvatinib and pembrolizumab in the treatment of a 62-year-old patient with endometrioid adenocarcinoma who received first-line therapy with the combination of lenvatinib and pembrolizumab in the absence of repair system deficiency after adjuvant therapy. This combination offers the potential to extend survival in patients with mismatch repair proficient endometrial cancer who have received systemic neoadjuvant or adjuvant therapy. |
| format | Article |
| id | doaj-art-9a71ad1b5d2c455ab1daea46d077adc2 |
| institution | Kabale University |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| publishDate | 2025-05-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj-art-9a71ad1b5d2c455ab1daea46d077adc22025-08-20T03:38:26ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272025-05-0121114214610.17650/1994-4098-2025-21-1-142-146903Lenvatinib in combination with pembrolizumab as first-line therapy for advanced endometrial cancer: clinical caseE. A. Khachaturyan0T. G. Antonova1O. A. Stativko2I. A. Pokataev3Oncology Center No. 1, S. S. Yudin City Clinical Hospital, Moscow Healthcare DepartmentOncology Center No. 1, S. S. Yudin City Clinical Hospital, Moscow Healthcare DepartmentOncology Center No. 1, S. S. Yudin City Clinical Hospital, Moscow Healthcare DepartmentOncology Center No. 1, S. S. Yudin City Clinical Hospital, Moscow Healthcare DepartmentThe combination of lenvatinib and pembrolizumab has emerged as the first non-chemo treatment for advanced endometrial cancer, particularly in cases refractory to standard therapies. This case describes the efficacy and safety of the combination of lenvatinib and pembrolizumab in the treatment of a 62-year-old patient with endometrioid adenocarcinoma who received first-line therapy with the combination of lenvatinib and pembrolizumab in the absence of repair system deficiency after adjuvant therapy. This combination offers the potential to extend survival in patients with mismatch repair proficient endometrial cancer who have received systemic neoadjuvant or adjuvant therapy.https://ojrs.abvpress.ru/ojrs/article/view/1356targeted therapypembrolizumablenvatinibendometrial cancerroutine clinical practice |
| spellingShingle | E. A. Khachaturyan T. G. Antonova O. A. Stativko I. A. Pokataev Lenvatinib in combination with pembrolizumab as first-line therapy for advanced endometrial cancer: clinical case Опухоли женской репродуктивной системы targeted therapy pembrolizumab lenvatinib endometrial cancer routine clinical practice |
| title | Lenvatinib in combination with pembrolizumab as first-line therapy for advanced endometrial cancer: clinical case |
| title_full | Lenvatinib in combination with pembrolizumab as first-line therapy for advanced endometrial cancer: clinical case |
| title_fullStr | Lenvatinib in combination with pembrolizumab as first-line therapy for advanced endometrial cancer: clinical case |
| title_full_unstemmed | Lenvatinib in combination with pembrolizumab as first-line therapy for advanced endometrial cancer: clinical case |
| title_short | Lenvatinib in combination with pembrolizumab as first-line therapy for advanced endometrial cancer: clinical case |
| title_sort | lenvatinib in combination with pembrolizumab as first line therapy for advanced endometrial cancer clinical case |
| topic | targeted therapy pembrolizumab lenvatinib endometrial cancer routine clinical practice |
| url | https://ojrs.abvpress.ru/ojrs/article/view/1356 |
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