Fine-Tuning Reception in the Bone: PPARγ and Company

PPARγ plays a central role in the formation of fat. Regulation of PPARγ activity depends on numerous factors ranging from dietary ligands to nuclear hormone coactivators and corepressors to oxygen-sensing mechanisms. In addition, the interplay of PPARγ with other nuclear hormone receptors has implic...

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Main Authors: Z. Elizabeth Floyd, Sanjin Zvonic, Mark E. Nuttall, Jeffrey M. Gimble
Format: Article
Language:English
Published: Wiley 2006-01-01
Series:PPAR Research
Online Access:http://dx.doi.org/10.1155/PPAR/2006/52950
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author Z. Elizabeth Floyd
Sanjin Zvonic
Mark E. Nuttall
Jeffrey M. Gimble
author_facet Z. Elizabeth Floyd
Sanjin Zvonic
Mark E. Nuttall
Jeffrey M. Gimble
author_sort Z. Elizabeth Floyd
collection DOAJ
description PPARγ plays a central role in the formation of fat. Regulation of PPARγ activity depends on numerous factors ranging from dietary ligands to nuclear hormone coactivators and corepressors to oxygen-sensing mechanisms. In addition, the interplay of PPARγ with other nuclear hormone receptors has implications for the balance between adipogenesis and osteogenesis in mesenchymal stem cells of the bone marrow stroma. This review will explore a range of factors influencing PPARγ activity and how these interactions may affect osteogenesis.
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institution Kabale University
issn 1687-4757
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language English
publishDate 2006-01-01
publisher Wiley
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series PPAR Research
spelling doaj-art-9a6cdaba569e40f0a573f7a579e0cd602025-02-03T05:46:20ZengWileyPPAR Research1687-47571687-47652006-01-01200610.1155/PPAR/2006/5295052950Fine-Tuning Reception in the Bone: PPARγ and CompanyZ. Elizabeth Floyd0Sanjin Zvonic1Mark E. Nuttall2Jeffrey M. Gimble3Stem Cell Laboratory, Pennington Biomedical Research Center, Baton Rouge 70808, LA, USAStem Cell Laboratory, Pennington Biomedical Research Center, Baton Rouge 70808, LA, USACentocor, Johnson and Johnson, Horsham 19044, PA, USAStem Cell Laboratory, Pennington Biomedical Research Center, Baton Rouge 70808, LA, USAPPARγ plays a central role in the formation of fat. Regulation of PPARγ activity depends on numerous factors ranging from dietary ligands to nuclear hormone coactivators and corepressors to oxygen-sensing mechanisms. In addition, the interplay of PPARγ with other nuclear hormone receptors has implications for the balance between adipogenesis and osteogenesis in mesenchymal stem cells of the bone marrow stroma. This review will explore a range of factors influencing PPARγ activity and how these interactions may affect osteogenesis.http://dx.doi.org/10.1155/PPAR/2006/52950
spellingShingle Z. Elizabeth Floyd
Sanjin Zvonic
Mark E. Nuttall
Jeffrey M. Gimble
Fine-Tuning Reception in the Bone: PPARγ and Company
PPAR Research
title Fine-Tuning Reception in the Bone: PPARγ and Company
title_full Fine-Tuning Reception in the Bone: PPARγ and Company
title_fullStr Fine-Tuning Reception in the Bone: PPARγ and Company
title_full_unstemmed Fine-Tuning Reception in the Bone: PPARγ and Company
title_short Fine-Tuning Reception in the Bone: PPARγ and Company
title_sort fine tuning reception in the bone pparγ and company
url http://dx.doi.org/10.1155/PPAR/2006/52950
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AT markenuttall finetuningreceptionintheboneppargandcompany
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