Fine-Tuning Reception in the Bone: PPARγ and Company
PPARγ plays a central role in the formation of fat. Regulation of PPARγ activity depends on numerous factors ranging from dietary ligands to nuclear hormone coactivators and corepressors to oxygen-sensing mechanisms. In addition, the interplay of PPARγ with other nuclear hormone receptors has implic...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2006-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/PPAR/2006/52950 |
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| Summary: | PPARγ plays a central role in the formation of fat.
Regulation of PPARγ activity depends on numerous factors
ranging from dietary ligands to nuclear hormone coactivators and
corepressors to oxygen-sensing mechanisms. In addition, the
interplay of PPARγ with other nuclear hormone receptors
has implications for the balance between adipogenesis and
osteogenesis in mesenchymal stem cells of the bone marrow stroma.
This review will explore a range of factors influencing
PPARγ activity and how these interactions may affect
osteogenesis. |
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| ISSN: | 1687-4757 1687-4765 |