Resveratrol and its derivates improve inflammatory bowel disease by targeting gut microbiota and inflammatory signaling pathways
Inflammatory bowel disease (IBD) is a chronic inflammatory lesion of the intestine, mainly manifested by infiltration of intestinal inflammatory cells and imbalance of gut microbiota. Conventional treatments for IBD include antibiotics, immunosuppressive agents, 5-aminosalicylic acid, steroids and s...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2022-01-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453021000690 |
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| author | Ming Li Ping Li Rongxue Tang Hui Lu |
| author_facet | Ming Li Ping Li Rongxue Tang Hui Lu |
| author_sort | Ming Li |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD) is a chronic inflammatory lesion of the intestine, mainly manifested by infiltration of intestinal inflammatory cells and imbalance of gut microbiota. Conventional treatments for IBD include antibiotics, immunosuppressive agents, 5-aminosalicylic acid, steroids and surgery, which have high toxic side effects. Resveratrol is a natural polyphenol, and its various derivatives have anti-oxidation and anti-inflammatory properties. In this paper, we comprehensively review the mechanism of resveratrol and its derivates to alleviate IBD by improving intestinal barrier, regulating the unbalanced gut microbiota, and targeting various inflammatory signaling pathways. |
| format | Article |
| id | doaj-art-9a66155fae8b4873a3c6f0da16a542ef |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-9a66155fae8b4873a3c6f0da16a542ef2025-02-02T23:24:54ZengTsinghua University PressFood Science and Human Wellness2213-45302022-01-011112231Resveratrol and its derivates improve inflammatory bowel disease by targeting gut microbiota and inflammatory signaling pathwaysMing Li0Ping Li1Rongxue Tang2Hui Lu3State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, ChinaState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, ChinaState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, ChinaCorresponding author at: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.; State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, ChinaInflammatory bowel disease (IBD) is a chronic inflammatory lesion of the intestine, mainly manifested by infiltration of intestinal inflammatory cells and imbalance of gut microbiota. Conventional treatments for IBD include antibiotics, immunosuppressive agents, 5-aminosalicylic acid, steroids and surgery, which have high toxic side effects. Resveratrol is a natural polyphenol, and its various derivatives have anti-oxidation and anti-inflammatory properties. In this paper, we comprehensively review the mechanism of resveratrol and its derivates to alleviate IBD by improving intestinal barrier, regulating the unbalanced gut microbiota, and targeting various inflammatory signaling pathways.http://www.sciencedirect.com/science/article/pii/S2213453021000690ResveratrolInflammatory bowel diseaseIntestinal barrierGut microbiotaInflammatory signaling pathways |
| spellingShingle | Ming Li Ping Li Rongxue Tang Hui Lu Resveratrol and its derivates improve inflammatory bowel disease by targeting gut microbiota and inflammatory signaling pathways Food Science and Human Wellness Resveratrol Inflammatory bowel disease Intestinal barrier Gut microbiota Inflammatory signaling pathways |
| title | Resveratrol and its derivates improve inflammatory bowel disease by targeting gut microbiota and inflammatory signaling pathways |
| title_full | Resveratrol and its derivates improve inflammatory bowel disease by targeting gut microbiota and inflammatory signaling pathways |
| title_fullStr | Resveratrol and its derivates improve inflammatory bowel disease by targeting gut microbiota and inflammatory signaling pathways |
| title_full_unstemmed | Resveratrol and its derivates improve inflammatory bowel disease by targeting gut microbiota and inflammatory signaling pathways |
| title_short | Resveratrol and its derivates improve inflammatory bowel disease by targeting gut microbiota and inflammatory signaling pathways |
| title_sort | resveratrol and its derivates improve inflammatory bowel disease by targeting gut microbiota and inflammatory signaling pathways |
| topic | Resveratrol Inflammatory bowel disease Intestinal barrier Gut microbiota Inflammatory signaling pathways |
| url | http://www.sciencedirect.com/science/article/pii/S2213453021000690 |
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