The Effectiveness of Poly-(4-vinyl-N-hexylpyridiniumbromide) as an Antibacterial Implant Coating: An In Vitro Study
The clinical success of osseointegrated dental implants depends on the strong attachment of the surrounding hard and soft tissues. Bacterial adhesion on implant surfaces can cause inflammatory reactions and may influence healing and long-term success of dental implants. Promising implant coatings sh...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2011/859140 |
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| author | L. Ringenberg A. Winkel O. Kufelt P. Behrens M. Stiesch W. Heuer |
| author_facet | L. Ringenberg A. Winkel O. Kufelt P. Behrens M. Stiesch W. Heuer |
| author_sort | L. Ringenberg |
| collection | DOAJ |
| description | The clinical success of osseointegrated dental implants depends on the strong attachment of the surrounding hard and soft tissues. Bacterial adhesion on implant surfaces can cause inflammatory reactions and may influence healing and long-term success of dental implants. Promising implant coatings should minimize bacterial adhesion, but allow epithelial and connective tissue attachment. Therefore, the present study has examined the bioactive effect of poly-(4-vinyl-N-hexylpyridiniumbromide) regarding typical oral bacteria as well as cytotoxicitiy to human cells considering different methods of connecting polymers to silicate-containing surfaces. The results revealed that the application of putative antibacterial and biocompatible polymer in coating strategies is affected by a variety of parameters. Published findings regarding reduced bacterial adhesion could not be verified using oral pathogens whereas hexylated polymers seem problematic for strong adhesion of soft tissue. Concerning innovative coatings for dental implants basic aspects (surface roughness, thickness, alkylation, combination with other polymers) have to be considered in further investigations. |
| format | Article |
| id | doaj-art-9a62bda5e3d34bedaa7d7b3fb44d1a8c |
| institution | OA Journals |
| issn | 1687-8728 1687-8736 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Dentistry |
| spelling | doaj-art-9a62bda5e3d34bedaa7d7b3fb44d1a8c2025-08-20T02:20:15ZengWileyInternational Journal of Dentistry1687-87281687-87362011-01-01201110.1155/2011/859140859140The Effectiveness of Poly-(4-vinyl-N-hexylpyridiniumbromide) as an Antibacterial Implant Coating: An In Vitro StudyL. Ringenberg0A. Winkel1O. Kufelt2P. Behrens3M. Stiesch4W. Heuer5Department of Prosthetic Dentistry and Biomedical Material Science, Hannover Medical School, 30625 Hannover, GermanyDepartment of Prosthetic Dentistry and Biomedical Material Science, Hannover Medical School, 30625 Hannover, GermanyInstitute of Inorganic Chemistry, Leibniz University Hannover, 30167 Hannover, GermanyInstitute of Inorganic Chemistry, Leibniz University Hannover, 30167 Hannover, GermanyDepartment of Prosthetic Dentistry and Biomedical Material Science, Hannover Medical School, 30625 Hannover, GermanyDepartment of Prosthetic Dentistry and Biomedical Material Science, Hannover Medical School, 30625 Hannover, GermanyThe clinical success of osseointegrated dental implants depends on the strong attachment of the surrounding hard and soft tissues. Bacterial adhesion on implant surfaces can cause inflammatory reactions and may influence healing and long-term success of dental implants. Promising implant coatings should minimize bacterial adhesion, but allow epithelial and connective tissue attachment. Therefore, the present study has examined the bioactive effect of poly-(4-vinyl-N-hexylpyridiniumbromide) regarding typical oral bacteria as well as cytotoxicitiy to human cells considering different methods of connecting polymers to silicate-containing surfaces. The results revealed that the application of putative antibacterial and biocompatible polymer in coating strategies is affected by a variety of parameters. Published findings regarding reduced bacterial adhesion could not be verified using oral pathogens whereas hexylated polymers seem problematic for strong adhesion of soft tissue. Concerning innovative coatings for dental implants basic aspects (surface roughness, thickness, alkylation, combination with other polymers) have to be considered in further investigations.http://dx.doi.org/10.1155/2011/859140 |
| spellingShingle | L. Ringenberg A. Winkel O. Kufelt P. Behrens M. Stiesch W. Heuer The Effectiveness of Poly-(4-vinyl-N-hexylpyridiniumbromide) as an Antibacterial Implant Coating: An In Vitro Study International Journal of Dentistry |
| title | The Effectiveness of Poly-(4-vinyl-N-hexylpyridiniumbromide) as an Antibacterial Implant Coating: An In Vitro Study |
| title_full | The Effectiveness of Poly-(4-vinyl-N-hexylpyridiniumbromide) as an Antibacterial Implant Coating: An In Vitro Study |
| title_fullStr | The Effectiveness of Poly-(4-vinyl-N-hexylpyridiniumbromide) as an Antibacterial Implant Coating: An In Vitro Study |
| title_full_unstemmed | The Effectiveness of Poly-(4-vinyl-N-hexylpyridiniumbromide) as an Antibacterial Implant Coating: An In Vitro Study |
| title_short | The Effectiveness of Poly-(4-vinyl-N-hexylpyridiniumbromide) as an Antibacterial Implant Coating: An In Vitro Study |
| title_sort | effectiveness of poly 4 vinyl n hexylpyridiniumbromide as an antibacterial implant coating an in vitro study |
| url | http://dx.doi.org/10.1155/2011/859140 |
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