Th2 cells and cytokine networks in allergic inflammation of the lung
The cytokines released from Th2 and Th2-like cells are likely to be central to the pathophysiolgy of asthma and allergy, contributing to aberrant IgE production, eosinophilia and, perhaps, mucosal susceptibility to viral infection. IL-4 has emerged as a central target, not only for B cell IgE produc...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1995-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S096293519500038X |
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| _version_ | 1832564836606672896 |
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| author | Anthony J. Coyle Shogo Tsuyuki |
| author_facet | Anthony J. Coyle Shogo Tsuyuki |
| author_sort | Anthony J. Coyle |
| collection | DOAJ |
| description | The cytokines released from Th2 and Th2-like cells are likely to be central to the pathophysiolgy of asthma and allergy, contributing to aberrant IgE production, eosinophilia and, perhaps, mucosal susceptibility to viral infection. IL-4 has emerged as a central target, not only for B cell IgE production, but also in the commitment of both CD4+ and CD8+ T cells to cells with Th2 effector function capable of secreting IL-5 resultlng in eosinophilic inflammation. In view of the central role of this cytokine and the evidence that glucocorticoids are unable to modify many IL-4 dependent effects, Th2 inhibitors may prove to be novel therapies for the treatment of bronchial asthma. |
| format | Article |
| id | doaj-art-9a622b8a66054208877b7c5d2038895e |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1995-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-9a622b8a66054208877b7c5d2038895e2025-02-03T01:10:01ZengWileyMediators of Inflammation0962-93511466-18611995-01-014423924710.1155/S096293519500038XTh2 cells and cytokine networks in allergic inflammation of the lungAnthony J. Coyle0Shogo Tsuyuki1Asthma and Allergy Research Department, CIBA-GEIGY AG, Basel CH-4002, SwitzerlandDept. of Research, Kissei Pharmaceutical, Nagano Prefecture, Matsumoto, JapanThe cytokines released from Th2 and Th2-like cells are likely to be central to the pathophysiolgy of asthma and allergy, contributing to aberrant IgE production, eosinophilia and, perhaps, mucosal susceptibility to viral infection. IL-4 has emerged as a central target, not only for B cell IgE production, but also in the commitment of both CD4+ and CD8+ T cells to cells with Th2 effector function capable of secreting IL-5 resultlng in eosinophilic inflammation. In view of the central role of this cytokine and the evidence that glucocorticoids are unable to modify many IL-4 dependent effects, Th2 inhibitors may prove to be novel therapies for the treatment of bronchial asthma.http://dx.doi.org/10.1155/S096293519500038X |
| spellingShingle | Anthony J. Coyle Shogo Tsuyuki Th2 cells and cytokine networks in allergic inflammation of the lung Mediators of Inflammation |
| title | Th2 cells and cytokine networks in allergic inflammation of the lung |
| title_full | Th2 cells and cytokine networks in allergic inflammation of the lung |
| title_fullStr | Th2 cells and cytokine networks in allergic inflammation of the lung |
| title_full_unstemmed | Th2 cells and cytokine networks in allergic inflammation of the lung |
| title_short | Th2 cells and cytokine networks in allergic inflammation of the lung |
| title_sort | th2 cells and cytokine networks in allergic inflammation of the lung |
| url | http://dx.doi.org/10.1155/S096293519500038X |
| work_keys_str_mv | AT anthonyjcoyle th2cellsandcytokinenetworksinallergicinflammationofthelung AT shogotsuyuki th2cellsandcytokinenetworksinallergicinflammationofthelung |