Innovative adjuvant strategies for next-generation pertussis vaccines
The acellular pertussis (aP) vaccine has increasingly replaced the whole-cell pertussis (wP) vaccine due to its superior safety profile. However, the aP vaccine is less effective at preventing infection and transmission of Bordetella pertussis, highlighting the need for more effective aP vaccines. C...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2025.2545636 |
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| _version_ | 1849239734621044736 |
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| author | Ge Yu Wenqi Yang Yubin Ma Ning Zhang Di Tang Ye Jin Liang Shi Mengshu Wang Dawei Liu Changying Xue Bingbing Sun |
| author_facet | Ge Yu Wenqi Yang Yubin Ma Ning Zhang Di Tang Ye Jin Liang Shi Mengshu Wang Dawei Liu Changying Xue Bingbing Sun |
| author_sort | Ge Yu |
| collection | DOAJ |
| description | The acellular pertussis (aP) vaccine has increasingly replaced the whole-cell pertussis (wP) vaccine due to its superior safety profile. However, the aP vaccine is less effective at preventing infection and transmission of Bordetella pertussis, highlighting the need for more effective aP vaccines. Current aP vaccines do not elicit the robust cellular immunity necessary to eliminate intracellular bacteria and do not induce sufficient mucosal immunity to prevent bacterial colonization in the upper respiratory tract. Incorporating novel adjuvants represents a promising avenue for the future development of pertussis vaccines. Nevertheless, there remains a significant gap in understanding the application of novel adjuvants. In this article, we summarize the currently approved pertussis vaccines, focusing on the types of antigens and adjuvants used, and discuss the mechanisms of novel adjuvants. This provides valuable insights into the roles of adjuvants in pertussis vaccines, laying a foundation for designing next-generation pertussis vaccines with improved adjuvant systems. |
| format | Article |
| id | doaj-art-9a5da60e9a1b4acbb87bc32b6f6d06a2 |
| institution | Kabale University |
| issn | 2164-5515 2164-554X |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj-art-9a5da60e9a1b4acbb87bc32b6f6d06a22025-08-20T04:00:51ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2025-12-0121110.1080/21645515.2025.2545636Innovative adjuvant strategies for next-generation pertussis vaccinesGe Yu0Wenqi Yang1Yubin Ma2Ning Zhang3Di Tang4Ye Jin5Liang Shi6Mengshu Wang7Dawei Liu8Changying Xue9Bingbing Sun10State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, ChinaState Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, ChinaState Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, ChinaState Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, ChinaState Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, ChinaSchool of Life and Health, Dalian University, Dalian, ChinaQuality System, Changchun BCHT Biotechnology Co., Changchun, ChinaQuality System, Changchun BCHT Biotechnology Co., Changchun, ChinaQuality System, Changchun BCHT Biotechnology Co., Changchun, ChinaSchool of Bioengineering, Dalian University of Technology, Dalian, ChinaState Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, ChinaThe acellular pertussis (aP) vaccine has increasingly replaced the whole-cell pertussis (wP) vaccine due to its superior safety profile. However, the aP vaccine is less effective at preventing infection and transmission of Bordetella pertussis, highlighting the need for more effective aP vaccines. Current aP vaccines do not elicit the robust cellular immunity necessary to eliminate intracellular bacteria and do not induce sufficient mucosal immunity to prevent bacterial colonization in the upper respiratory tract. Incorporating novel adjuvants represents a promising avenue for the future development of pertussis vaccines. Nevertheless, there remains a significant gap in understanding the application of novel adjuvants. In this article, we summarize the currently approved pertussis vaccines, focusing on the types of antigens and adjuvants used, and discuss the mechanisms of novel adjuvants. This provides valuable insights into the roles of adjuvants in pertussis vaccines, laying a foundation for designing next-generation pertussis vaccines with improved adjuvant systems.https://www.tandfonline.com/doi/10.1080/21645515.2025.2545636Pertussis vaccinescombined vaccinesadjuvantsmucosal immunityformulationvaccine stability |
| spellingShingle | Ge Yu Wenqi Yang Yubin Ma Ning Zhang Di Tang Ye Jin Liang Shi Mengshu Wang Dawei Liu Changying Xue Bingbing Sun Innovative adjuvant strategies for next-generation pertussis vaccines Human Vaccines & Immunotherapeutics Pertussis vaccines combined vaccines adjuvants mucosal immunity formulation vaccine stability |
| title | Innovative adjuvant strategies for next-generation pertussis vaccines |
| title_full | Innovative adjuvant strategies for next-generation pertussis vaccines |
| title_fullStr | Innovative adjuvant strategies for next-generation pertussis vaccines |
| title_full_unstemmed | Innovative adjuvant strategies for next-generation pertussis vaccines |
| title_short | Innovative adjuvant strategies for next-generation pertussis vaccines |
| title_sort | innovative adjuvant strategies for next generation pertussis vaccines |
| topic | Pertussis vaccines combined vaccines adjuvants mucosal immunity formulation vaccine stability |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2025.2545636 |
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