Roles of lactylation in lipid metabolism and related diseases
Abstract Lipids are indispensable molecules that play key roles in cell physiology by acting as structural elements, energy reservoirs, and participants in signal transduction. Recent studies have identified lactylation as a novel post-translational modification crucial for maintaining cellular and...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2025-08-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-025-02705-4 |
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| _version_ | 1849226662752813056 |
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| author | Bing Zhao Zhuoqing Lan Caixia Li Hao Wang |
| author_facet | Bing Zhao Zhuoqing Lan Caixia Li Hao Wang |
| author_sort | Bing Zhao |
| collection | DOAJ |
| description | Abstract Lipids are indispensable molecules that play key roles in cell physiology by acting as structural elements, energy reservoirs, and participants in signal transduction. Recent studies have identified lactylation as a novel post-translational modification crucial for maintaining cellular and tissue equilibrium. Research has shown that lactylation regulates the turnover of proteins and lipids integral to lipid metabolism. However, comprehensive reviews addressing the complex relationship between lactylation and lipid metabolism are lacking. In this review, we summarize current findings regarding the influence of lactylation on lipid metabolism and the regulatory mechanisms. Further exploration of the intricate mechanisms underlying the role of lactylation in lipid metabolism, alongside the development of lactylation-targeted therapies, could provide innovative approaches to manage diseases linked to dysregulated lipid metabolism. |
| format | Article |
| id | doaj-art-9a54710cffa84bbc93f70c8a01cb6963 |
| institution | Kabale University |
| issn | 2058-7716 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj-art-9a54710cffa84bbc93f70c8a01cb69632025-08-24T11:08:15ZengNature Publishing GroupCell Death Discovery2058-77162025-08-0111111310.1038/s41420-025-02705-4Roles of lactylation in lipid metabolism and related diseasesBing Zhao0Zhuoqing Lan1Caixia Li2Hao Wang3Department of Anesthesiology, the First Affiliated Hospital, Zhejiang University School of MedicineDepartment of General Practice Medicine, the Fourth Affiliated Hospital, Zhejiang University School of MedicineDepartment of Anesthesiology, the First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Neurology, Tongde Hospital of Zhejiang ProvinceAbstract Lipids are indispensable molecules that play key roles in cell physiology by acting as structural elements, energy reservoirs, and participants in signal transduction. Recent studies have identified lactylation as a novel post-translational modification crucial for maintaining cellular and tissue equilibrium. Research has shown that lactylation regulates the turnover of proteins and lipids integral to lipid metabolism. However, comprehensive reviews addressing the complex relationship between lactylation and lipid metabolism are lacking. In this review, we summarize current findings regarding the influence of lactylation on lipid metabolism and the regulatory mechanisms. Further exploration of the intricate mechanisms underlying the role of lactylation in lipid metabolism, alongside the development of lactylation-targeted therapies, could provide innovative approaches to manage diseases linked to dysregulated lipid metabolism.https://doi.org/10.1038/s41420-025-02705-4 |
| spellingShingle | Bing Zhao Zhuoqing Lan Caixia Li Hao Wang Roles of lactylation in lipid metabolism and related diseases Cell Death Discovery |
| title | Roles of lactylation in lipid metabolism and related diseases |
| title_full | Roles of lactylation in lipid metabolism and related diseases |
| title_fullStr | Roles of lactylation in lipid metabolism and related diseases |
| title_full_unstemmed | Roles of lactylation in lipid metabolism and related diseases |
| title_short | Roles of lactylation in lipid metabolism and related diseases |
| title_sort | roles of lactylation in lipid metabolism and related diseases |
| url | https://doi.org/10.1038/s41420-025-02705-4 |
| work_keys_str_mv | AT bingzhao rolesoflactylationinlipidmetabolismandrelateddiseases AT zhuoqinglan rolesoflactylationinlipidmetabolismandrelateddiseases AT caixiali rolesoflactylationinlipidmetabolismandrelateddiseases AT haowang rolesoflactylationinlipidmetabolismandrelateddiseases |