Toll-like receptor 4 signaling activation domains promote CAR T cell function against solid tumors

Toll-like receptor 4 signaling activation domains promote CAR T cell function against solid tumors

Chimeric antigen receptor (CAR) T cell therapy has emerged as a powerful therapeutic approach against a range of hematologic malignancies. While the incorporation of CD28 or 4-1BB costimulatory signaling domains into CARs revolutionized immune responses, there is an exciting prospect of further enha...

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Bibliographic Details
Main Authors: Veronika Mikolič, Jelica Pantović-Žalig, Špela Malenšek, Matjaž Sever, Duško Lainšček, Roman Jerala
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Molecular Therapy: Oncology
Subjects:
CAR T cell therapy
cancer immunotherapy
innate immunity
TLR
costimulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2950329924000572
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