Task based evaluation of sparse view CT reconstruction techniques for intracranial hemorrhage diagnosis using an AI observer model
Abstract Sparse-view computed tomography (CT) holds promise for reducing radiation exposure and enabling novel system designs. Traditional reconstruction algorithms, including Filtered Backprojection (FBP) and Model-Based Iterative Reconstruction (MBIR), often produce artifacts in sparse-view data....
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| Format: | Article |
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Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-025-11089-5 |
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| author | Matthew Tivnan Irene Désirée Kikkert Dufan Wu Kai Yang Jelmer M. Wolterink Quanzheng Li Rajiv Gupta |
| author_facet | Matthew Tivnan Irene Désirée Kikkert Dufan Wu Kai Yang Jelmer M. Wolterink Quanzheng Li Rajiv Gupta |
| author_sort | Matthew Tivnan |
| collection | DOAJ |
| description | Abstract Sparse-view computed tomography (CT) holds promise for reducing radiation exposure and enabling novel system designs. Traditional reconstruction algorithms, including Filtered Backprojection (FBP) and Model-Based Iterative Reconstruction (MBIR), often produce artifacts in sparse-view data. Deep Learning Reconstruction (DLR) offers potential improvements, but task-based evaluations of DLR in sparse-view CT remain limited. This study employs an Artificial Intelligence (AI) observer to evaluate the diagnostic accuracy of FBP, MBIR, and DLR for intracranial hemorrhage detection and classification, offering a cost-effective alternative to human radiologist studies. A public brain CT dataset with labeled intracranial hemorrhages was used to train an AI observer model. Sparse-view CT data were simulated, with reconstructions performed using FBP, MBIR, and DLR. Reconstruction quality was assessed using metrics such as Peak Signal-to-Noise Ratio (PSNR), Structural Similarity Index Measure (SSIM), and Learned Perceptual Image Patch Similarity (LPIPS). Diagnostic utility was evaluated using Receiver Operating Characteristic (ROC) analysis and Area Under the Curve (AUC) values for One-vs-Rest and One-vs-One classification tasks. DLR outperformed FBP and MBIR in all quality metrics, demonstrating reduced noise, improved structural similarity, and fewer artifacts. The AI observer achieved the highest classification accuracy with DLR, while FBP surpassed MBIR in task-based accuracy despite inferior image quality metrics, emphasizing the value of task-based evaluations. DLR provides an effective balance of artifact reduction and anatomical detail in sparse-view CT brain imaging. This proof-of-concept study highlights AI observer models as a viable, cost-effective alternative for evaluating CT reconstruction techniques. |
| format | Article |
| id | doaj-art-9a50b09a17aa497d86adedec69fbceb1 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-9a50b09a17aa497d86adedec69fbceb12025-08-20T03:05:25ZengNature PortfolioScientific Reports2045-23222025-07-0115111010.1038/s41598-025-11089-5Task based evaluation of sparse view CT reconstruction techniques for intracranial hemorrhage diagnosis using an AI observer modelMatthew Tivnan0Irene Désirée Kikkert1Dufan Wu2Kai Yang3Jelmer M. Wolterink4Quanzheng Li5Rajiv Gupta6Radiology Department, Harvard Medical School & Massachusetts General HospitalDepartment of Applied Mathematics, Technical Medical Center, University of TwenteRadiology Department, Harvard Medical School & Massachusetts General HospitalRadiology Department, Harvard Medical School & Massachusetts General HospitalDepartment of Applied Mathematics, Technical Medical Center, University of TwenteRadiology Department, Harvard Medical School & Massachusetts General HospitalRadiology Department, Harvard Medical School & Massachusetts General HospitalAbstract Sparse-view computed tomography (CT) holds promise for reducing radiation exposure and enabling novel system designs. Traditional reconstruction algorithms, including Filtered Backprojection (FBP) and Model-Based Iterative Reconstruction (MBIR), often produce artifacts in sparse-view data. Deep Learning Reconstruction (DLR) offers potential improvements, but task-based evaluations of DLR in sparse-view CT remain limited. This study employs an Artificial Intelligence (AI) observer to evaluate the diagnostic accuracy of FBP, MBIR, and DLR for intracranial hemorrhage detection and classification, offering a cost-effective alternative to human radiologist studies. A public brain CT dataset with labeled intracranial hemorrhages was used to train an AI observer model. Sparse-view CT data were simulated, with reconstructions performed using FBP, MBIR, and DLR. Reconstruction quality was assessed using metrics such as Peak Signal-to-Noise Ratio (PSNR), Structural Similarity Index Measure (SSIM), and Learned Perceptual Image Patch Similarity (LPIPS). Diagnostic utility was evaluated using Receiver Operating Characteristic (ROC) analysis and Area Under the Curve (AUC) values for One-vs-Rest and One-vs-One classification tasks. DLR outperformed FBP and MBIR in all quality metrics, demonstrating reduced noise, improved structural similarity, and fewer artifacts. The AI observer achieved the highest classification accuracy with DLR, while FBP surpassed MBIR in task-based accuracy despite inferior image quality metrics, emphasizing the value of task-based evaluations. DLR provides an effective balance of artifact reduction and anatomical detail in sparse-view CT brain imaging. This proof-of-concept study highlights AI observer models as a viable, cost-effective alternative for evaluating CT reconstruction techniques.https://doi.org/10.1038/s41598-025-11089-5 |
| spellingShingle | Matthew Tivnan Irene Désirée Kikkert Dufan Wu Kai Yang Jelmer M. Wolterink Quanzheng Li Rajiv Gupta Task based evaluation of sparse view CT reconstruction techniques for intracranial hemorrhage diagnosis using an AI observer model Scientific Reports |
| title | Task based evaluation of sparse view CT reconstruction techniques for intracranial hemorrhage diagnosis using an AI observer model |
| title_full | Task based evaluation of sparse view CT reconstruction techniques for intracranial hemorrhage diagnosis using an AI observer model |
| title_fullStr | Task based evaluation of sparse view CT reconstruction techniques for intracranial hemorrhage diagnosis using an AI observer model |
| title_full_unstemmed | Task based evaluation of sparse view CT reconstruction techniques for intracranial hemorrhage diagnosis using an AI observer model |
| title_short | Task based evaluation of sparse view CT reconstruction techniques for intracranial hemorrhage diagnosis using an AI observer model |
| title_sort | task based evaluation of sparse view ct reconstruction techniques for intracranial hemorrhage diagnosis using an ai observer model |
| url | https://doi.org/10.1038/s41598-025-11089-5 |
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