AF6 regulates intestinal IgA via crosstalk between intestinal epithelial cells and immune cells in inflammatory bowel disease
Summary: The pathogenic factors of inflammatory bowel disease (IBD) are very complex, and further investigation of its pathogenesis is necessary. Some polar proteins have been reported to perform functions other than maintaining cell structure. In this study, we reported that the polar protein AF6 e...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-07-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004225009198 |
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| author | Liying Lu Keying Xu Huiheng Qu Lele Song Yanan Song Yanjun Wu Xia Sun Jingwen Kong Qian Wen Jiazheng Jiao Zhanju Liu Jiazeng Xia Lixing Zhan |
| author_facet | Liying Lu Keying Xu Huiheng Qu Lele Song Yanan Song Yanjun Wu Xia Sun Jingwen Kong Qian Wen Jiazheng Jiao Zhanju Liu Jiazeng Xia Lixing Zhan |
| author_sort | Liying Lu |
| collection | DOAJ |
| description | Summary: The pathogenic factors of inflammatory bowel disease (IBD) are very complex, and further investigation of its pathogenesis is necessary. Some polar proteins have been reported to perform functions other than maintaining cell structure. In this study, we reported that the polar protein AF6 expressed by intestinal epithelial cells (IEC) can regulate the expression of MHCII in epithelial cells, thus affecting the cross dialogue between IECs and immune cells, and promoting the secretion of IgA by B cells to play a protective function. IgA supplementation can also improve the severe colitis phenotype caused by AF6 loss. Our study provides an understanding of the regulatory mechanisms of the intestinal epithelial expression of MHC II and its important role in colitis, which will aid in treatment and intervention. |
| format | Article |
| id | doaj-art-9a4f97e0a7604812bdff207c2ff7108a |
| institution | DOAJ |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-9a4f97e0a7604812bdff207c2ff7108a2025-08-20T03:15:42ZengElsevieriScience2589-00422025-07-0128711265810.1016/j.isci.2025.112658AF6 regulates intestinal IgA via crosstalk between intestinal epithelial cells and immune cells in inflammatory bowel diseaseLiying Lu0Keying Xu1Huiheng Qu2Lele Song3Yanan Song4Yanjun Wu5Xia Sun6Jingwen Kong7Qian Wen8Jiazheng Jiao9Zhanju Liu10Jiazeng Xia11Lixing Zhan12Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, ChinaShanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, ChinaDepartment of General Surgery, JiangNan University Medical Center, No. 68 Zhongshan Road, Liangxi District, Wuxi, Jiangsu Province 214000, ChinaShanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, ChinaShanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, ChinaShanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, ChinaShanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, ChinaShanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, ChinaShanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, ChinaShanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, ChinaDepartment of Gastroenterology, The Shanghai Tenth People’s Hospital, Tongji University, Shanghai 200072, ChinaDepartment of General Surgery, JiangNan University Medical Center, No. 68 Zhongshan Road, Liangxi District, Wuxi, Jiangsu Province 214000, ChinaShanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China; Corresponding authorSummary: The pathogenic factors of inflammatory bowel disease (IBD) are very complex, and further investigation of its pathogenesis is necessary. Some polar proteins have been reported to perform functions other than maintaining cell structure. In this study, we reported that the polar protein AF6 expressed by intestinal epithelial cells (IEC) can regulate the expression of MHCII in epithelial cells, thus affecting the cross dialogue between IECs and immune cells, and promoting the secretion of IgA by B cells to play a protective function. IgA supplementation can also improve the severe colitis phenotype caused by AF6 loss. Our study provides an understanding of the regulatory mechanisms of the intestinal epithelial expression of MHC II and its important role in colitis, which will aid in treatment and intervention.http://www.sciencedirect.com/science/article/pii/S2589004225009198ImmunologyCell biology |
| spellingShingle | Liying Lu Keying Xu Huiheng Qu Lele Song Yanan Song Yanjun Wu Xia Sun Jingwen Kong Qian Wen Jiazheng Jiao Zhanju Liu Jiazeng Xia Lixing Zhan AF6 regulates intestinal IgA via crosstalk between intestinal epithelial cells and immune cells in inflammatory bowel disease iScience Immunology Cell biology |
| title | AF6 regulates intestinal IgA via crosstalk between intestinal epithelial cells and immune cells in inflammatory bowel disease |
| title_full | AF6 regulates intestinal IgA via crosstalk between intestinal epithelial cells and immune cells in inflammatory bowel disease |
| title_fullStr | AF6 regulates intestinal IgA via crosstalk between intestinal epithelial cells and immune cells in inflammatory bowel disease |
| title_full_unstemmed | AF6 regulates intestinal IgA via crosstalk between intestinal epithelial cells and immune cells in inflammatory bowel disease |
| title_short | AF6 regulates intestinal IgA via crosstalk between intestinal epithelial cells and immune cells in inflammatory bowel disease |
| title_sort | af6 regulates intestinal iga via crosstalk between intestinal epithelial cells and immune cells in inflammatory bowel disease |
| topic | Immunology Cell biology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004225009198 |
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