AduCPI2 alleviates MSU-induced acute gouty arthritis in mice by inhibiting cathepsin S and the C5a-C5aR1 axis

AduCPI2 alleviates MSU-induced acute gouty arthritis in mice by inhibiting cathepsin S and the C5a-C5aR1 axis

BackgroundGout, a prevalent and severe form of arthritis precipitated by hyperuricemia, has been the subject of extensive research. However, the intricate underlying mechanisms governing gout-related inflammation are still only partially elucidated. Ancylostoma duodenale cysteine protease inhibitor...

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Bibliographic Details
Main Authors: Sijing Liu, Yongli Situ, Li Deng, Meng Liang, Haoyuan He, Zheng Shao, Lifei Peng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
cysteine protease inhibitor
C5a-C5aR1 axis
cathepsin S
gouty arthritis
mice
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1604329/full
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